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Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting

The formation of single-stranded DNA (ssDNA) at double-strand break (DSB) ends is essential in repair by homologous recombination and is mediated by DNA helicases and nucleases. Here we estimated the length of ssDNA generated during DSB repair and analyzed the consequences of elimination of processi...

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Detalles Bibliográficos
Autores principales:	Chung, Woo-Hyun, Zhu, Zhu, Papusha, Alma, Malkova, Anna, Ira, Grzegorz
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869328/ https://www.ncbi.nlm.nih.gov/pubmed/20485519 http://dx.doi.org/10.1371/journal.pgen.1000948

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