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Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea
Cardiac and respiratory rhythms reveal transient phases of phase-locking which were proposed to be an important aspect of cardiorespiratory interaction. The aim of this study was to quantify cardio-respiratory phase-locking in obstructive sleep apnea (OSA). We investigated overnight polysomnography...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869347/ https://www.ncbi.nlm.nih.gov/pubmed/20485528 http://dx.doi.org/10.1371/journal.pone.0010602 |
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author | Kabir, Muammar M. Dimitri, Hany Sanders, Prashanthan Antic, Ral Nalivaiko, Eugene Abbott, Derek Baumert, Mathias |
author_facet | Kabir, Muammar M. Dimitri, Hany Sanders, Prashanthan Antic, Ral Nalivaiko, Eugene Abbott, Derek Baumert, Mathias |
author_sort | Kabir, Muammar M. |
collection | PubMed |
description | Cardiac and respiratory rhythms reveal transient phases of phase-locking which were proposed to be an important aspect of cardiorespiratory interaction. The aim of this study was to quantify cardio-respiratory phase-locking in obstructive sleep apnea (OSA). We investigated overnight polysomnography data of 248 subjects with suspected OSA. Cardiorespiratory phase-coupling was computed from the R-R intervals of body surface ECG and respiratory rate, calculated from abdominal and thoracic sensors, using Hilbert transform. A significant reduction in phase-coupling was observed in patients with severe OSA compared to patients with no or mild OSA. Cardiorespiratory phase-coupling was also associated with sleep stages and was significantly reduced during rapid-eye-movement (REM) sleep compared to slow-wave (SW) sleep. There was, however, no effect of age and BMI on phase coupling. Our study suggests that the assessment of cardiorespiratory phase coupling may be used as an ECG based screening tool for determining the severity of OSA. |
format | Text |
id | pubmed-2869347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-28693472010-05-19 Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea Kabir, Muammar M. Dimitri, Hany Sanders, Prashanthan Antic, Ral Nalivaiko, Eugene Abbott, Derek Baumert, Mathias PLoS One Research Article Cardiac and respiratory rhythms reveal transient phases of phase-locking which were proposed to be an important aspect of cardiorespiratory interaction. The aim of this study was to quantify cardio-respiratory phase-locking in obstructive sleep apnea (OSA). We investigated overnight polysomnography data of 248 subjects with suspected OSA. Cardiorespiratory phase-coupling was computed from the R-R intervals of body surface ECG and respiratory rate, calculated from abdominal and thoracic sensors, using Hilbert transform. A significant reduction in phase-coupling was observed in patients with severe OSA compared to patients with no or mild OSA. Cardiorespiratory phase-coupling was also associated with sleep stages and was significantly reduced during rapid-eye-movement (REM) sleep compared to slow-wave (SW) sleep. There was, however, no effect of age and BMI on phase coupling. Our study suggests that the assessment of cardiorespiratory phase coupling may be used as an ECG based screening tool for determining the severity of OSA. Public Library of Science 2010-05-13 /pmc/articles/PMC2869347/ /pubmed/20485528 http://dx.doi.org/10.1371/journal.pone.0010602 Text en Kabir et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kabir, Muammar M. Dimitri, Hany Sanders, Prashanthan Antic, Ral Nalivaiko, Eugene Abbott, Derek Baumert, Mathias Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea |
title | Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea |
title_full | Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea |
title_fullStr | Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea |
title_full_unstemmed | Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea |
title_short | Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea |
title_sort | cardiorespiratory phase-coupling is reduced in patients with obstructive sleep apnea |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869347/ https://www.ncbi.nlm.nih.gov/pubmed/20485528 http://dx.doi.org/10.1371/journal.pone.0010602 |
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