Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al(2)O(3) under inspection

Although a plethora of synthetic procedures mediated by KF-loaded aluminas is available in the literature, there is almost no data concerning the influence of parameters such as alumina modification or KF-loading on experimental results. Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction...

Descripción completa

Detalles Bibliográficos
Autores principales: Bernhardt, Franziska, Trotzki, Ronald, Szuppa, Tony, Stolle, Achim, Ondruschka, Bernd
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2010
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870998/
https://www.ncbi.nlm.nih.gov/pubmed/20485589
http://dx.doi.org/10.3762/bjoc.6.7
_version_ 1782181134853996544
author Bernhardt, Franziska
Trotzki, Ronald
Szuppa, Tony
Stolle, Achim
Ondruschka, Bernd
author_facet Bernhardt, Franziska
Trotzki, Ronald
Szuppa, Tony
Stolle, Achim
Ondruschka, Bernd
author_sort Bernhardt, Franziska
collection PubMed
description Although a plethora of synthetic procedures mediated by KF-loaded aluminas is available in the literature, there is almost no data concerning the influence of parameters such as alumina modification or KF-loading on experimental results. Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction was chosen as model reaction to investigate the effect of the above mentioned parameters on the results of coupling reactions. The results from ball milling experiments led to the conclusion that self-prepared and commercially available KF–Al(2)O(3) differ in water content. The higher the residual water content, the higher are the product yields.
format Text
id pubmed-2870998
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-28709982010-05-18 Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al(2)O(3) under inspection Bernhardt, Franziska Trotzki, Ronald Szuppa, Tony Stolle, Achim Ondruschka, Bernd Beilstein J Org Chem Full Research Paper Although a plethora of synthetic procedures mediated by KF-loaded aluminas is available in the literature, there is almost no data concerning the influence of parameters such as alumina modification or KF-loading on experimental results. Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction was chosen as model reaction to investigate the effect of the above mentioned parameters on the results of coupling reactions. The results from ball milling experiments led to the conclusion that self-prepared and commercially available KF–Al(2)O(3) differ in water content. The higher the residual water content, the higher are the product yields. Beilstein-Institut 2010-01-22 /pmc/articles/PMC2870998/ /pubmed/20485589 http://dx.doi.org/10.3762/bjoc.6.7 Text en Copyright © 2010, Bernhardt et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Bernhardt, Franziska
Trotzki, Ronald
Szuppa, Tony
Stolle, Achim
Ondruschka, Bernd
Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al(2)O(3) under inspection
title Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al(2)O(3) under inspection
title_full Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al(2)O(3) under inspection
title_fullStr Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al(2)O(3) under inspection
title_full_unstemmed Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al(2)O(3) under inspection
title_short Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al(2)O(3) under inspection
title_sort solvent-free and time-efficient suzuki–miyaura reaction in a ball mill: the solid reagent system kf–al(2)o(3) under inspection
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870998/
https://www.ncbi.nlm.nih.gov/pubmed/20485589
http://dx.doi.org/10.3762/bjoc.6.7
work_keys_str_mv AT bernhardtfranziska solventfreeandtimeefficientsuzukimiyaurareactioninaballmillthesolidreagentsystemkfal2o3underinspection
AT trotzkironald solventfreeandtimeefficientsuzukimiyaurareactioninaballmillthesolidreagentsystemkfal2o3underinspection
AT szuppatony solventfreeandtimeefficientsuzukimiyaurareactioninaballmillthesolidreagentsystemkfal2o3underinspection
AT stolleachim solventfreeandtimeefficientsuzukimiyaurareactioninaballmillthesolidreagentsystemkfal2o3underinspection
AT ondruschkabernd solventfreeandtimeefficientsuzukimiyaurareactioninaballmillthesolidreagentsystemkfal2o3underinspection

Ejemplares similares