Distamycin A Inhibits HMGA1-Binding to the P-Selectin Promoter and Attenuates Lung and Liver Inflammation during Murine Endotoxemia

BACKGROUND: The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes (“enhanceosomes”) that upregulate expression of select genes within the inflammatory cascade during critical illness syndromes such as a...

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Detalles Bibliográficos
Autores principales: Baron, Rebecca M., Lopez-Guzman, Silvia, Riascos, Dario F., Macias, Alvaro A., Layne, Matthew D., Cheng, Guiying, Harris, Cailin, Chung, Su Wol, Reeves, Raymond, von Andrian, Ulrich H., Perrella, Mark A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871042/
https://www.ncbi.nlm.nih.gov/pubmed/20498830
http://dx.doi.org/10.1371/journal.pone.0010656

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