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Heritability of chronic venous disease
Varicose veins without skin changes have a prevalence of approximately 20% in Northern and Western Europe whereas advanced chronic venous insufficiency affects about 3% of the population. Genetic risk factors are thought to play an important role in the aetiology of both these chronic venous disease...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871097/ https://www.ncbi.nlm.nih.gov/pubmed/20354728 http://dx.doi.org/10.1007/s00439-010-0812-9 |
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author | Fiebig, Andreas Krusche, Petra Wolf, Andreas Krawczak, Michael Timm, Birgitt Nikolaus, Susanna Frings, Norbert Schreiber, Stefan |
author_facet | Fiebig, Andreas Krusche, Petra Wolf, Andreas Krawczak, Michael Timm, Birgitt Nikolaus, Susanna Frings, Norbert Schreiber, Stefan |
author_sort | Fiebig, Andreas |
collection | PubMed |
description | Varicose veins without skin changes have a prevalence of approximately 20% in Northern and Western Europe whereas advanced chronic venous insufficiency affects about 3% of the population. Genetic risk factors are thought to play an important role in the aetiology of both these chronic venous diseases (CVD). We evaluated the relative genetic and environmental impact upon CVD risk by estimating the heritability of the disease in 4,033 nuclear families, comprising 16,434 individuals from all over Germany. Upon clinical examination, patients were classified according to the CEAP guidelines as either C2 (simple varicose veins), C3 (oedema), C4 (skin changes without ulceration), C5 (healed ulceration), or C6 (active ulcers). The narrow-sense heritability (h (2)) of CVD equals 17.3% (standard error 2.5%, likelihood ratio test P = 1.4 × 10(−13)). The proportion of disease risk attributable to age (at ascertainment) and sex, the two main risk factors for CVD, was estimated as 10.7% (Kullback–Leibler deviance R (2)). The heritability of CVD is high, thereby suggesting a notable genetic component in the aetiology of the disease. Systematic population-based searches for CVD susceptibility genes are therefore warranted. |
format | Text |
id | pubmed-2871097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-28710972010-05-26 Heritability of chronic venous disease Fiebig, Andreas Krusche, Petra Wolf, Andreas Krawczak, Michael Timm, Birgitt Nikolaus, Susanna Frings, Norbert Schreiber, Stefan Hum Genet Original Investigation Varicose veins without skin changes have a prevalence of approximately 20% in Northern and Western Europe whereas advanced chronic venous insufficiency affects about 3% of the population. Genetic risk factors are thought to play an important role in the aetiology of both these chronic venous diseases (CVD). We evaluated the relative genetic and environmental impact upon CVD risk by estimating the heritability of the disease in 4,033 nuclear families, comprising 16,434 individuals from all over Germany. Upon clinical examination, patients were classified according to the CEAP guidelines as either C2 (simple varicose veins), C3 (oedema), C4 (skin changes without ulceration), C5 (healed ulceration), or C6 (active ulcers). The narrow-sense heritability (h (2)) of CVD equals 17.3% (standard error 2.5%, likelihood ratio test P = 1.4 × 10(−13)). The proportion of disease risk attributable to age (at ascertainment) and sex, the two main risk factors for CVD, was estimated as 10.7% (Kullback–Leibler deviance R (2)). The heritability of CVD is high, thereby suggesting a notable genetic component in the aetiology of the disease. Systematic population-based searches for CVD susceptibility genes are therefore warranted. Springer-Verlag 2010-03-31 2010 /pmc/articles/PMC2871097/ /pubmed/20354728 http://dx.doi.org/10.1007/s00439-010-0812-9 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Investigation Fiebig, Andreas Krusche, Petra Wolf, Andreas Krawczak, Michael Timm, Birgitt Nikolaus, Susanna Frings, Norbert Schreiber, Stefan Heritability of chronic venous disease |
title | Heritability of chronic venous disease |
title_full | Heritability of chronic venous disease |
title_fullStr | Heritability of chronic venous disease |
title_full_unstemmed | Heritability of chronic venous disease |
title_short | Heritability of chronic venous disease |
title_sort | heritability of chronic venous disease |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871097/ https://www.ncbi.nlm.nih.gov/pubmed/20354728 http://dx.doi.org/10.1007/s00439-010-0812-9 |
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