A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response to persistent transcription-blocking DNA damage, although the relevant lesion...

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Detalles Bibliográficos
Autores principales: Fensgård, Øyvind, Kassahun, Henok, Bombik, Izabela, Rognes, Torbjørn, Lindvall, Jessica Margareta, Nilsen, Hilde
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871243/
https://www.ncbi.nlm.nih.gov/pubmed/20382984

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