Direct determination of molecular haplotypes by chromosome microdissection

Direct observation of haplotypes is still technical challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determine human haplotypes with more than 98.85% accuracy at 24,245 heterozygous single-nucleotide polymorphism (SNP) loci in genome-wid...

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Detalles Bibliográficos
Autores principales: Ma, Li, Xiao, Yan, Huang, Hui, Wang, Qingwei, Rao, Weinian, Feng, Yue, Zhang, Kui, Song, Qing
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871314/
https://www.ncbi.nlm.nih.gov/pubmed/20305652
http://dx.doi.org/10.1038/nmeth.1443
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author Ma, Li
Xiao, Yan
Huang, Hui
Wang, Qingwei
Rao, Weinian
Feng, Yue
Zhang, Kui
Song, Qing
author_facet Ma, Li
Xiao, Yan
Huang, Hui
Wang, Qingwei
Rao, Weinian
Feng, Yue
Zhang, Kui
Song, Qing
author_sort Ma, Li
collection PubMed
description Direct observation of haplotypes is still technical challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determine human haplotypes with more than 98.85% accuracy at 24,245 heterozygous single-nucleotide polymorphism (SNP) loci in genome-wide chromosome-range phasing distance.
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spelling pubmed-28713142010-10-01 Direct determination of molecular haplotypes by chromosome microdissection Ma, Li Xiao, Yan Huang, Hui Wang, Qingwei Rao, Weinian Feng, Yue Zhang, Kui Song, Qing Nat Methods Article Direct observation of haplotypes is still technical challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determine human haplotypes with more than 98.85% accuracy at 24,245 heterozygous single-nucleotide polymorphism (SNP) loci in genome-wide chromosome-range phasing distance. 2010-03-21 2010-04 /pmc/articles/PMC2871314/ /pubmed/20305652 http://dx.doi.org/10.1038/nmeth.1443 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ma, Li
Xiao, Yan
Huang, Hui
Wang, Qingwei
Rao, Weinian
Feng, Yue
Zhang, Kui
Song, Qing
Direct determination of molecular haplotypes by chromosome microdissection
title Direct determination of molecular haplotypes by chromosome microdissection
title_full Direct determination of molecular haplotypes by chromosome microdissection
title_fullStr Direct determination of molecular haplotypes by chromosome microdissection
title_full_unstemmed Direct determination of molecular haplotypes by chromosome microdissection
title_short Direct determination of molecular haplotypes by chromosome microdissection
title_sort direct determination of molecular haplotypes by chromosome microdissection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871314/
https://www.ncbi.nlm.nih.gov/pubmed/20305652
http://dx.doi.org/10.1038/nmeth.1443
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