Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer

α,2-3- and α,2-6-sialylated lactosaminide precursor structures obtained by various enzymatic procedures could be used for glycosylations employing triflic acid/N-iodosuccinimide. Easily accessible selectively protected lactoside derivatives served as acceptor disaccharides to give the corresponding...

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Autores principales: Schmidt, Dirk, Thiem, Joachim
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2010
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871369/
https://www.ncbi.nlm.nih.gov/pubmed/20485600
http://dx.doi.org/10.3762/bjoc.6.18
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author Schmidt, Dirk
Thiem, Joachim
author_facet Schmidt, Dirk
Thiem, Joachim
author_sort Schmidt, Dirk
collection PubMed
description α,2-3- and α,2-6-sialylated lactosaminide precursor structures obtained by various enzymatic procedures could be used for glycosylations employing triflic acid/N-iodosuccinimide. Easily accessible selectively protected lactoside derivatives served as acceptor disaccharides to give the corresponding human milk pentasaccharides in good yields. These were characterized by spectroscopic means in the form of their peracetylated derivatives.
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spelling pubmed-28713692010-05-18 Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer Schmidt, Dirk Thiem, Joachim Beilstein J Org Chem Full Research Paper α,2-3- and α,2-6-sialylated lactosaminide precursor structures obtained by various enzymatic procedures could be used for glycosylations employing triflic acid/N-iodosuccinimide. Easily accessible selectively protected lactoside derivatives served as acceptor disaccharides to give the corresponding human milk pentasaccharides in good yields. These were characterized by spectroscopic means in the form of their peracetylated derivatives. Beilstein-Institut 2010-02-22 /pmc/articles/PMC2871369/ /pubmed/20485600 http://dx.doi.org/10.3762/bjoc.6.18 Text en Copyright © 2010, Schmidt and Thiem https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Schmidt, Dirk
Thiem, Joachim
Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer
title Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer
title_full Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer
title_fullStr Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer
title_full_unstemmed Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer
title_short Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer
title_sort chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-n-tetraose and sialyllacto-n-neotetraose epimer
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871369/
https://www.ncbi.nlm.nih.gov/pubmed/20485600
http://dx.doi.org/10.3762/bjoc.6.18
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AT thiemjoachim chemicalsynthesisusingenzymaticallygeneratedbuildingunitsforconstructionofthehumanmilkpentasaccharidessialyllactontetraoseandsialyllactonneotetraoseepimer

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