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Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia. A subset of patients with lone AF have no overt heart disease and an increased heritability of AF. We sought to identify common genetic variants underlying lone AF. Cases were from the German AF Network, Heart and Vascular Health Stud...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/ https://www.ncbi.nlm.nih.gov/pubmed/20173747 http://dx.doi.org/10.1038/ng.537 |
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| author | Ellinor, Patrick T. Lunetta, Kathryn L. Glazer, Nicole L. Pfeufer, Arne Alonso, Alvaro Chung, Mina K. Sinner, Moritz F. de Bakker, Paul I. W. Mueller, Martina Lubitz, Steven A. Fox, Ervin Darbar, Dawood Smith, Nicholas L. Smith, Jonathan D. Schnabel, Renate B. Soliman, Elsayed Z. Rice, Kenneth M. Van Wagoner, David R. Beckmann, Britt-M. van Noord, Charlotte Wang, Ke Ehret, Georg B. Rotter, Jerome I. Hazen, Stanley L. Steinbeck, Gerhard Smith, Albert V. Launer, Lenore J. Harris, Tamara B. Makino, Seiko Nelis, Mari Milan, David J. Perz, Siegfried Esko, Tõnu Köttgen, Anna Moebus, Susanne Newton-Cheh, Christopher Li, Man Möhlenkamp, Stefan Wang, Thomas J. Kao, W.H. Linda Vasan, Ramachandran S. Nöthen, Markus M. MacRae, Calum A. Stricker, Bruno H. Ch. Hofman, Albert Uitterlinden, André G. Levy, Daniel Boerwinkle, Eric Metspalu, Andres Topol, Eric J. Chakravarti, Aravinda Gudnason, Vilmundur Psaty, Bruce M. Roden, Dan M. Meitinger, Thomas Wichmann, H.-Erich Witteman, Jacqueline C.M. Barnard, John Arking, Dan E. Benjamin, Emelia J. Heckbert, Susan R. Kääb, Stefan |
| author_facet | Ellinor, Patrick T. Lunetta, Kathryn L. Glazer, Nicole L. Pfeufer, Arne Alonso, Alvaro Chung, Mina K. Sinner, Moritz F. de Bakker, Paul I. W. Mueller, Martina Lubitz, Steven A. Fox, Ervin Darbar, Dawood Smith, Nicholas L. Smith, Jonathan D. Schnabel, Renate B. Soliman, Elsayed Z. Rice, Kenneth M. Van Wagoner, David R. Beckmann, Britt-M. van Noord, Charlotte Wang, Ke Ehret, Georg B. Rotter, Jerome I. Hazen, Stanley L. Steinbeck, Gerhard Smith, Albert V. Launer, Lenore J. Harris, Tamara B. Makino, Seiko Nelis, Mari Milan, David J. Perz, Siegfried Esko, Tõnu Köttgen, Anna Moebus, Susanne Newton-Cheh, Christopher Li, Man Möhlenkamp, Stefan Wang, Thomas J. Kao, W.H. Linda Vasan, Ramachandran S. Nöthen, Markus M. MacRae, Calum A. Stricker, Bruno H. Ch. Hofman, Albert Uitterlinden, André G. Levy, Daniel Boerwinkle, Eric Metspalu, Andres Topol, Eric J. Chakravarti, Aravinda Gudnason, Vilmundur Psaty, Bruce M. Roden, Dan M. Meitinger, Thomas Wichmann, H.-Erich Witteman, Jacqueline C.M. Barnard, John Arking, Dan E. Benjamin, Emelia J. Heckbert, Susan R. Kääb, Stefan |
| author_sort | Ellinor, Patrick T. |
| collection | PubMed |
| description | Atrial fibrillation (AF) is the most common sustained arrhythmia. A subset of patients with lone AF have no overt heart disease and an increased heritability of AF. We sought to identify common genetic variants underlying lone AF. Cases were from the German AF Network, Heart and Vascular Health Study, Atherosclerosis Risk in Communities Study, Cleveland Clinic, and Massachusetts General Hospital. Subjects were genotyped, HapMap SNPs imputed, and age- sex- and hypertension-adjusted analyses performed. A meta-analysis was conducted using 1,335 cases of lone AF and 12,844 referents. A novel locus on chromosome 1q21 was identified, and the most significant SNP, rs13376333, had an adjusted odds ratio of 1.56 (P=6.3×10(−12)). This association was replicated in two cohorts with lone AF for an overall odds ratio of 1.52 (P=1.83×10(−21)). Rs13376333 is intronic to KCNN3, a potassium channel involved in atrial repolarization. KCNN3 represents a novel potential therapeutic target in the treatment of AF. |
| format | Text |
| id | pubmed-2871387 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28713872010-09-01 Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation Ellinor, Patrick T. Lunetta, Kathryn L. Glazer, Nicole L. Pfeufer, Arne Alonso, Alvaro Chung, Mina K. Sinner, Moritz F. de Bakker, Paul I. W. Mueller, Martina Lubitz, Steven A. Fox, Ervin Darbar, Dawood Smith, Nicholas L. Smith, Jonathan D. Schnabel, Renate B. Soliman, Elsayed Z. Rice, Kenneth M. Van Wagoner, David R. Beckmann, Britt-M. van Noord, Charlotte Wang, Ke Ehret, Georg B. Rotter, Jerome I. Hazen, Stanley L. Steinbeck, Gerhard Smith, Albert V. Launer, Lenore J. Harris, Tamara B. Makino, Seiko Nelis, Mari Milan, David J. Perz, Siegfried Esko, Tõnu Köttgen, Anna Moebus, Susanne Newton-Cheh, Christopher Li, Man Möhlenkamp, Stefan Wang, Thomas J. Kao, W.H. Linda Vasan, Ramachandran S. Nöthen, Markus M. MacRae, Calum A. Stricker, Bruno H. Ch. Hofman, Albert Uitterlinden, André G. Levy, Daniel Boerwinkle, Eric Metspalu, Andres Topol, Eric J. Chakravarti, Aravinda Gudnason, Vilmundur Psaty, Bruce M. Roden, Dan M. Meitinger, Thomas Wichmann, H.-Erich Witteman, Jacqueline C.M. Barnard, John Arking, Dan E. Benjamin, Emelia J. Heckbert, Susan R. Kääb, Stefan Nat Genet Article Atrial fibrillation (AF) is the most common sustained arrhythmia. A subset of patients with lone AF have no overt heart disease and an increased heritability of AF. We sought to identify common genetic variants underlying lone AF. Cases were from the German AF Network, Heart and Vascular Health Study, Atherosclerosis Risk in Communities Study, Cleveland Clinic, and Massachusetts General Hospital. Subjects were genotyped, HapMap SNPs imputed, and age- sex- and hypertension-adjusted analyses performed. A meta-analysis was conducted using 1,335 cases of lone AF and 12,844 referents. A novel locus on chromosome 1q21 was identified, and the most significant SNP, rs13376333, had an adjusted odds ratio of 1.56 (P=6.3×10(−12)). This association was replicated in two cohorts with lone AF for an overall odds ratio of 1.52 (P=1.83×10(−21)). Rs13376333 is intronic to KCNN3, a potassium channel involved in atrial repolarization. KCNN3 represents a novel potential therapeutic target in the treatment of AF. 2010-02-21 2010-03 /pmc/articles/PMC2871387/ /pubmed/20173747 http://dx.doi.org/10.1038/ng.537 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Ellinor, Patrick T. Lunetta, Kathryn L. Glazer, Nicole L. Pfeufer, Arne Alonso, Alvaro Chung, Mina K. Sinner, Moritz F. de Bakker, Paul I. W. Mueller, Martina Lubitz, Steven A. Fox, Ervin Darbar, Dawood Smith, Nicholas L. Smith, Jonathan D. Schnabel, Renate B. Soliman, Elsayed Z. Rice, Kenneth M. Van Wagoner, David R. Beckmann, Britt-M. van Noord, Charlotte Wang, Ke Ehret, Georg B. Rotter, Jerome I. Hazen, Stanley L. Steinbeck, Gerhard Smith, Albert V. Launer, Lenore J. Harris, Tamara B. Makino, Seiko Nelis, Mari Milan, David J. Perz, Siegfried Esko, Tõnu Köttgen, Anna Moebus, Susanne Newton-Cheh, Christopher Li, Man Möhlenkamp, Stefan Wang, Thomas J. Kao, W.H. Linda Vasan, Ramachandran S. Nöthen, Markus M. MacRae, Calum A. Stricker, Bruno H. Ch. Hofman, Albert Uitterlinden, André G. Levy, Daniel Boerwinkle, Eric Metspalu, Andres Topol, Eric J. Chakravarti, Aravinda Gudnason, Vilmundur Psaty, Bruce M. Roden, Dan M. Meitinger, Thomas Wichmann, H.-Erich Witteman, Jacqueline C.M. Barnard, John Arking, Dan E. Benjamin, Emelia J. Heckbert, Susan R. Kääb, Stefan Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation |
| title | Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation |
| title_full | Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation |
| title_fullStr | Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation |
| title_full_unstemmed | Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation |
| title_short | Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation |
| title_sort | common variants in kcnn3 are associated with lone atrial fibrillation |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/ https://www.ncbi.nlm.nih.gov/pubmed/20173747 http://dx.doi.org/10.1038/ng.537 |
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