Endoplasmic Reticulum Export, Subcellular Distribution, and Fibril Formation by Pmel17 Require an Intact N-terminal Domain Junction

Pmel17 is a melanocyte/melanoma-specific protein that subcellularly localizes to melanosomes, where it forms a fibrillar matrix that serves for the sequestration of potentially toxic reaction intermediates of melanin synthesis and deposition of the pigment. As a key factor in melanosomal biogenesis,...

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Detalles Bibliográficos
Autores principales: Leonhardt, Ralf M., Vigneron, Nathalie, Rahner, Christoph, Van den Eynde, Benoît J., Cresswell, Peter
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871485/
https://www.ncbi.nlm.nih.gov/pubmed/20231267
http://dx.doi.org/10.1074/jbc.M109.097725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871485/
https://www.ncbi.nlm.nih.gov/pubmed/20231267
http://dx.doi.org/10.1074/jbc.M109.097725

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