Robust and specific inhibition of microRNAs in Caenorhabditis elegans

MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence, Zheng and colleagues demonstrate a technique for robust and specific...

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Detalles Bibliográficos
Autores principales: Kundu, Samrat T, Slack, Frank J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871512/
https://www.ncbi.nlm.nih.gov/pubmed/20359318
http://dx.doi.org/10.1186/jbiol230
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author Kundu, Samrat T
Slack, Frank J
author_facet Kundu, Samrat T
Slack, Frank J
author_sort Kundu, Samrat T
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence, Zheng and colleagues demonstrate a technique for robust and specific knockdown of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a powerful tool for the study of regulation and function of miRNAs in vivo. See research article http://www.silencejournal.com/content/1/1/9
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spelling pubmed-28715122010-10-01 Robust and specific inhibition of microRNAs in Caenorhabditis elegans Kundu, Samrat T Slack, Frank J J Biol Minireview MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence, Zheng and colleagues demonstrate a technique for robust and specific knockdown of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a powerful tool for the study of regulation and function of miRNAs in vivo. See research article http://www.silencejournal.com/content/1/1/9 BioMed Central 2010 2010-04-01 /pmc/articles/PMC2871512/ /pubmed/20359318 http://dx.doi.org/10.1186/jbiol230 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Minireview
Kundu, Samrat T
Slack, Frank J
Robust and specific inhibition of microRNAs in Caenorhabditis elegans
title Robust and specific inhibition of microRNAs in Caenorhabditis elegans
title_full Robust and specific inhibition of microRNAs in Caenorhabditis elegans
title_fullStr Robust and specific inhibition of microRNAs in Caenorhabditis elegans
title_full_unstemmed Robust and specific inhibition of microRNAs in Caenorhabditis elegans
title_short Robust and specific inhibition of microRNAs in Caenorhabditis elegans
title_sort robust and specific inhibition of micrornas in caenorhabditis elegans
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871512/
https://www.ncbi.nlm.nih.gov/pubmed/20359318
http://dx.doi.org/10.1186/jbiol230
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