Cargando…

Polaprezinc Protects Mice against Endotoxin Shock

Polaprezinc (PZ), a chelate compound consisting of zinc and l-carnosine (Car), is an anti-ulcer drug developed in Japan. In the present study, we investigated whether PZ suppresses mortality, pulmonary inflammation, and plasma nitric oxide (NO) and tumor necrosis factor (TNF)-α levels in endotoxin s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ohata, Shuzo, Moriyama, Chihiro, Yamashita, Atsushi, Nishida, Tadashi, Kusumoto, Chiaki, Mochida, Shinsuke, Minami, Yukari, Nakada, Junya, Shomori, Kohei, Inagaki, Yoshimi, Ohta, Yoshiji, Matsura, Tatsuya
Formato:	Texto
Lenguaje:	English
Publicado:	the Society for Free Radical Research Japan 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872229/ https://www.ncbi.nlm.nih.gov/pubmed/20490319 http://dx.doi.org/10.3164/jcbn.09-125

Ejemplares similares

Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70
por: Nishida, Tadashi, et al.
Publicado: (2010)

Geranylgeranylacetone Ameliorates Inflammatory Response to Lipopolysaccharide (LPS) in Murine Macrophages: Inhibition of LPS Binding to The Cell Surface
por: Mochida, Shinsuke, et al.
Publicado: (2007)

Drug repositioning of polaprezinc for bone fracture healing
por: Ko, Eun Ae, et al.
Publicado: (2022)

Protection by Exogenously Added Coenzyme Q(9) against Free Radical-Induced Injuries in Human Liver Cells
por: Kusumoto, Chiaki, et al.
Publicado: (2010)

Compound 48/80, a mast cell degranulator, causes oxidative damage by enhancing vitamin C synthesis via reduced glutathione depletion and lipid peroxidation through neutrophil infiltration in rat livers
por: Ohta, Yosihiji, et al.
Publicado: (2017)

Desflurane inhalation before ischemia increases ischemia–reperfusion-induced vascular leakage in isolated rabbit lungs
por: Oshima, Yoshiaki, et al.
Publicado: (2016)

Polaprezinc protects normal intestinal epithelium against exposure to ionizing radiation in mice
por: Odawara, Soichi, et al.
Publicado: (2016)

Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane
por: Gao, Xue, et al.
Publicado: (2022)

Effects of polaprezinc on gastric mucosal damage and neurotransmitters in a rat model of chemotherapy-induced vomiting
por: Liu, Zhao Yang, et al.
Publicado: (2018)

Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial
por: Yoshikawa, Fumitsugu, et al.
Publicado: (2019)

Peripartum myocardial infarction associated with coronary spasm and acquired protein S deficiency: A case report
por: Oshima, Yoshiaki, et al.
Publicado: (2019)

Octacosanol Attenuates Disrupted Hepatic Reactive Oxygen Species Metabolism Associated with Acute Liver Injury Progression in Rats Intoxicated with Carbon Tetrachloride
por: Ohta, Yoshiji, et al.
Publicado: (2008)

The Effect of Quadruple Therapy with Polaprezinc or Bismuth on Gut Microbiota after Helicobacter pylori Eradication: A Randomized Controlled Trial
por: Wu, Dingkun, et al.
Publicado: (2022)

Zinc Acetate Hydrate Supplementation versus Polaprezinc Supplementation for Improving Hypozincemia in Hemodialysis Patients: A Randomized Clinical Trial
por: Kumagai, Etsuko, et al.
Publicado: (2023)

Saikokeishito Extract Exerts a Therapeutic Effect on α-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue
por: Ohta, Yoshiji, et al.
Publicado: (2007)

Heat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells
por: Qin, Ying, et al.
Publicado: (2011)

Cytoprotective effect of chlorogenic acid against α-synuclein-related toxicity in catecholaminergic PC12 cells
por: Teraoka, Mari, et al.
Publicado: (2012)

ADAMTS13, VWF, and Endotoxin Are Interrelated and Associated with the Severity of Liver Cirrhosis via Hypercoagulability
por: Takaya, Hiroaki, et al.
Publicado: (2022)

Preparation and clinical evaluation of a novel lozenge containing polaprezinc, a zinc-L-carnosine, for prevention of oral mucositis in patients with hematological cancer who received high-dose chemotherapy
por: Hayashi, Hiroko, et al.
Publicado: (2016)

Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study
por: Watari, Ikue, et al.
Publicado: (2013)

Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers
por: Jung, Da Hyun, et al.
Publicado: (2021)

Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein
por: Nakaso, Kazuhiro, et al.
Publicado: (2013)

Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis
por: Shibamoto, Akihiko, et al.
Publicado: (2023)

System x(c)(−) in microglia is a novel therapeutic target for post-septic neurological and psychiatric illness
por: Kitagawa, Yoshinori, et al.
Publicado: (2019)

Difficulty in Diagnosing and Treating a Prostate Abscess With Bacterial and Fungal Coinfection in an Immunocompromised Patient
por: Ohta, Ryuichi, et al.
Publicado: (2022)

Author reply to what are the clinical signs of thiamine deficiency in elderly patients?
por: Ohta, Ryuichi, et al.
Publicado: (2021)

Polaprezinc (Zinc–l-Carnosine Complex) as an Add-on Therapy for Binge Eating Disorder and Bulimia Nervosa, and the Possible Involvement of Zinc Deficiency in These Conditions: A Pilot Study
por: Sakae, Kensaku, et al.
Publicado: (2020)

Efficacy of quadruple regimen with polaprezinc for gastric Helicobacter pylori infection eradication: protocol for a single-centre, single-blind, non-inferiority, randomised clinical trial
por: Wu, Dingkun, et al.
Publicado: (2020)

Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
por: Mahmoud, Abdelrahman, et al.
Publicado: (2022)

Increased Endotoxin Activity Is Associated with the Risk of Developing Acute-on-Chronic Liver Failure
por: Takaya, Hiroaki, et al.
Publicado: (2020)

Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process
por: Tsuno, Satoshi, et al.
Publicado: (2014)

Retraction Note: Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process
por: Tsuno, Satoshi, et al.
Publicado: (2018)

Efficacy and Safety of Polaprezinc (Zinc Compound) on Zinc Deficiency: A Systematic Review and Dose–Response Meta-Analysis of Randomized Clinical Trials Using Individual Patient Data
por: Furihata, Kei, et al.
Publicado: (2020)

Maternal exercise training attenuates endotoxin-induced sepsis in mice offspring
por: Yamada, Mami, et al.
Publicado: (2018)

Clinical usefulness of measuring endotoxin activity on ICU admission
por: Murai, A, et al.
Publicado: (2012)

The association between sarcopenia and endotoxin in patients with alcoholic cirrhosis
por: Sato, Shinya, et al.
Publicado: (2021)

Measuring endotoxin with newly developed endotoxin scattering photometry
por: Kase, Y, et al.
Publicado: (2008)

Low Endotoxin Recovery—Masking of Naturally Occurring Endotoxin
por: Reich, Johannes, et al.
Publicado: (2019)

Plasma endotoxin activity in kangaroos with oral necrobacillosis (lumpy jaw disease) using an automated handheld testing system
por: SOTOHIRA, Yukari, et al.
Publicado: (2016)

Identification of the Genes Chemosensitizing Hepatocellular Carcinoma Cells to Interferon-α/5-Fluorouracil and Their Clinical Significance
por: Sakabe, Tomohiko, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_40p58n3rghtvo28hi0bccmkil7