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Maternal Diet, Behaviour and Offspring Skeletal Health

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in la...

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Detalles Bibliográficos
Autores principales: Goodfellow, Laura R., Earl, Susannah, Cooper, Cyrus, Harvey, Nicholas C.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872349/
https://www.ncbi.nlm.nih.gov/pubmed/20617058
http://dx.doi.org/10.3390/ijerph7041760
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author Goodfellow, Laura R.
Earl, Susannah
Cooper, Cyrus
Harvey, Nicholas C.
author_facet Goodfellow, Laura R.
Earl, Susannah
Cooper, Cyrus
Harvey, Nicholas C.
author_sort Goodfellow, Laura R.
collection PubMed
description Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.
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spelling pubmed-28723492010-07-08 Maternal Diet, Behaviour and Offspring Skeletal Health Goodfellow, Laura R. Earl, Susannah Cooper, Cyrus Harvey, Nicholas C. Int J Environ Res Public Health Review Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk. Molecular Diversity Preservation International (MDPI) 2010-04-16 2010-04 /pmc/articles/PMC2872349/ /pubmed/20617058 http://dx.doi.org/10.3390/ijerph7041760 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Goodfellow, Laura R.
Earl, Susannah
Cooper, Cyrus
Harvey, Nicholas C.
Maternal Diet, Behaviour and Offspring Skeletal Health
title Maternal Diet, Behaviour and Offspring Skeletal Health
title_full Maternal Diet, Behaviour and Offspring Skeletal Health
title_fullStr Maternal Diet, Behaviour and Offspring Skeletal Health
title_full_unstemmed Maternal Diet, Behaviour and Offspring Skeletal Health
title_short Maternal Diet, Behaviour and Offspring Skeletal Health
title_sort maternal diet, behaviour and offspring skeletal health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872349/
https://www.ncbi.nlm.nih.gov/pubmed/20617058
http://dx.doi.org/10.3390/ijerph7041760
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