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Maternal Diet, Behaviour and Offspring Skeletal Health
Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in la...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872349/ https://www.ncbi.nlm.nih.gov/pubmed/20617058 http://dx.doi.org/10.3390/ijerph7041760 |
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author | Goodfellow, Laura R. Earl, Susannah Cooper, Cyrus Harvey, Nicholas C. |
author_facet | Goodfellow, Laura R. Earl, Susannah Cooper, Cyrus Harvey, Nicholas C. |
author_sort | Goodfellow, Laura R. |
collection | PubMed |
description | Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk. |
format | Text |
id | pubmed-2872349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-28723492010-07-08 Maternal Diet, Behaviour and Offspring Skeletal Health Goodfellow, Laura R. Earl, Susannah Cooper, Cyrus Harvey, Nicholas C. Int J Environ Res Public Health Review Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk. Molecular Diversity Preservation International (MDPI) 2010-04-16 2010-04 /pmc/articles/PMC2872349/ /pubmed/20617058 http://dx.doi.org/10.3390/ijerph7041760 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Goodfellow, Laura R. Earl, Susannah Cooper, Cyrus Harvey, Nicholas C. Maternal Diet, Behaviour and Offspring Skeletal Health |
title | Maternal Diet, Behaviour and Offspring Skeletal Health |
title_full | Maternal Diet, Behaviour and Offspring Skeletal Health |
title_fullStr | Maternal Diet, Behaviour and Offspring Skeletal Health |
title_full_unstemmed | Maternal Diet, Behaviour and Offspring Skeletal Health |
title_short | Maternal Diet, Behaviour and Offspring Skeletal Health |
title_sort | maternal diet, behaviour and offspring skeletal health |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872349/ https://www.ncbi.nlm.nih.gov/pubmed/20617058 http://dx.doi.org/10.3390/ijerph7041760 |
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