Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy

Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 ve...

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Autores principales: Balbi, Massimiliano, Donadon, Valter, Ghersetti, Michela, Grazioli, Silvia, Valentina, Giovanni Della, Gardenal, Rita, Mas, Maria Dal, Casarin, Pietro, Zanette, Giorgio, Miranda, Cesare, Cimarosti, Paolo
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872357/
https://www.ncbi.nlm.nih.gov/pubmed/20617035
http://dx.doi.org/10.3390/ijerph7041366
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author Balbi, Massimiliano
Donadon, Valter
Ghersetti, Michela
Grazioli, Silvia
Valentina, Giovanni Della
Gardenal, Rita
Mas, Maria Dal
Casarin, Pietro
Zanette, Giorgio
Miranda, Cesare
Cimarosti, Paolo
author_facet Balbi, Massimiliano
Donadon, Valter
Ghersetti, Michela
Grazioli, Silvia
Valentina, Giovanni Della
Gardenal, Rita
Mas, Maria Dal
Casarin, Pietro
Zanette, Giorgio
Miranda, Cesare
Cimarosti, Paolo
author_sort Balbi, Massimiliano
collection PubMed
description Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection.
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spelling pubmed-28723572010-07-08 Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy Balbi, Massimiliano Donadon, Valter Ghersetti, Michela Grazioli, Silvia Valentina, Giovanni Della Gardenal, Rita Mas, Maria Dal Casarin, Pietro Zanette, Giorgio Miranda, Cesare Cimarosti, Paolo Int J Environ Res Public Health Article Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection. Molecular Diversity Preservation International (MDPI) 2010-03-29 2010-04 /pmc/articles/PMC2872357/ /pubmed/20617035 http://dx.doi.org/10.3390/ijerph7041366 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Balbi, Massimiliano
Donadon, Valter
Ghersetti, Michela
Grazioli, Silvia
Valentina, Giovanni Della
Gardenal, Rita
Mas, Maria Dal
Casarin, Pietro
Zanette, Giorgio
Miranda, Cesare
Cimarosti, Paolo
Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy
title Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy
title_full Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy
title_fullStr Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy
title_full_unstemmed Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy
title_short Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy
title_sort alcohol and hcv chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872357/
https://www.ncbi.nlm.nih.gov/pubmed/20617035
http://dx.doi.org/10.3390/ijerph7041366
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