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BOLD Responses to Negative Reward Prediction Errors in Human Habenula

Although positive reward prediction error, a key element in learning that is signaled by dopamine cells, has been extensively studied, little is known about negative reward prediction errors in humans. Detailed animal electrophysiology shows that the habenula, an integrative region involved in many...

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Detalles Bibliográficos
Autores principales: Salas, Ramiro, Baldwin, Philip, de Biasi, Mariella, Montague, P. Read
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872503/
https://www.ncbi.nlm.nih.gov/pubmed/20485575
http://dx.doi.org/10.3389/fnhum.2010.00036
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author Salas, Ramiro
Baldwin, Philip
de Biasi, Mariella
Montague, P. Read
author_facet Salas, Ramiro
Baldwin, Philip
de Biasi, Mariella
Montague, P. Read
author_sort Salas, Ramiro
collection PubMed
description Although positive reward prediction error, a key element in learning that is signaled by dopamine cells, has been extensively studied, little is known about negative reward prediction errors in humans. Detailed animal electrophysiology shows that the habenula, an integrative region involved in many processes including learning, reproduction, and stress responses, also encodes negative reward-related events such as negative reward prediction error signals. In humans, however, the habenula's extremely small size has prevented direct assessments of its function. We developed a method to functionally locate and study the habenula in humans using fMRI, based on the expected reward-dependent response phenomenology of habenula and striatum and, we provide conclusive evidence for activation in human habenula to negative reward prediction errors.
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spelling pubmed-28725032010-05-18 BOLD Responses to Negative Reward Prediction Errors in Human Habenula Salas, Ramiro Baldwin, Philip de Biasi, Mariella Montague, P. Read Front Hum Neurosci Neuroscience Although positive reward prediction error, a key element in learning that is signaled by dopamine cells, has been extensively studied, little is known about negative reward prediction errors in humans. Detailed animal electrophysiology shows that the habenula, an integrative region involved in many processes including learning, reproduction, and stress responses, also encodes negative reward-related events such as negative reward prediction error signals. In humans, however, the habenula's extremely small size has prevented direct assessments of its function. We developed a method to functionally locate and study the habenula in humans using fMRI, based on the expected reward-dependent response phenomenology of habenula and striatum and, we provide conclusive evidence for activation in human habenula to negative reward prediction errors. Frontiers Research Foundation 2010-05-11 /pmc/articles/PMC2872503/ /pubmed/20485575 http://dx.doi.org/10.3389/fnhum.2010.00036 Text en Copyright © 2010 Salas, Baldwin, de Biasi and Montague. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Salas, Ramiro
Baldwin, Philip
de Biasi, Mariella
Montague, P. Read
BOLD Responses to Negative Reward Prediction Errors in Human Habenula
title BOLD Responses to Negative Reward Prediction Errors in Human Habenula
title_full BOLD Responses to Negative Reward Prediction Errors in Human Habenula
title_fullStr BOLD Responses to Negative Reward Prediction Errors in Human Habenula
title_full_unstemmed BOLD Responses to Negative Reward Prediction Errors in Human Habenula
title_short BOLD Responses to Negative Reward Prediction Errors in Human Habenula
title_sort bold responses to negative reward prediction errors in human habenula
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872503/
https://www.ncbi.nlm.nih.gov/pubmed/20485575
http://dx.doi.org/10.3389/fnhum.2010.00036
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AT baldwinphilip boldresponsestonegativerewardpredictionerrorsinhumanhabenula
AT debiasimariella boldresponsestonegativerewardpredictionerrorsinhumanhabenula
AT montaguepread boldresponsestonegativerewardpredictionerrorsinhumanhabenula