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Transcript counting in single cells reveals dynamics of rDNA transcription

Most eukaryotes contain many tandem repeats of ribosomal RNA genes of which only a subset is transcribed at any given time. Current biochemical methods allow for the determination of the fraction of transcribing repeats (ON) versus non-transcribing repeats (OFF) but do not provide any dynamical info...

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Detalles Bibliográficos
Autores principales: Tan, Rui Zhen, van Oudenaarden, Alexander
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872610/
https://www.ncbi.nlm.nih.gov/pubmed/20393578
http://dx.doi.org/10.1038/msb.2010.14