Cargando…

Wnt4 and LAP2alpha as Pacemakers of Thymic Epithelial Senescence

Age-associated thymic involution has considerable physiological impact by inhibiting de novo T-cell selection. This impaired T-cell production leads to weakened immune responses. Yet the molecular mechanisms of thymic stromal adipose involution are not clear. Age-related alterations also occur in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kvell, Krisztian, Varecza, Zoltan, Bartis, Domokos, Hesse, Sebastian, Parnell, Sonia, Anderson, Graham, Jenkinson, Eric J., Pongracz, Judit E.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872673/ https://www.ncbi.nlm.nih.gov/pubmed/20502698 http://dx.doi.org/10.1371/journal.pone.0010701

Ejemplares similares

Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence
por: Varecza, Zoltan, et al.
Publicado: (2011)

Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescence
por: Kovacs, Tamas, et al.
Publicado: (2014)

PPARgamma Deficiency Counteracts Thymic Senescence
por: Ernszt, David, et al.
Publicado: (2017)

WNT signaling – lung cancer is no exception
por: Rapp, Judit, et al.
Publicado: (2017)

Down-Regulation of Canonical and Up-Regulation of Non-Canonical Wnt Signalling in the Carcinogenic Process of Squamous Cell Lung Carcinoma
por: Bartis, Domokos, et al.
Publicado: (2013)

Wnt signaling regulates trans-differentiation of stem cell like type 2 alveolar epithelial cells to type 1 epithelial cells
por: Abdelwahab, Elhusseiny Mohamed Mahmud, et al.
Publicado: (2019)

Cigarette Smoke-Induced Pulmonary Inflammation Becomes Systemic by Circulating Extracellular Vesicles Containing Wnt5a and Inflammatory Cytokines
por: Feller, Diana, et al.
Publicado: (2018)

Transgenic Exosomes for Thymus Regeneration
por: Banfai, Krisztina, et al.
Publicado: (2019)

Physical Activity as a Preventive Lifestyle Intervention Acts Through Specific Exosomal miRNA Species—Evidence From Human Short- and Long-Term Pilot Studies
por: Garai, Kitti, et al.
Publicado: (2021)

Corrigendum: Physical Activity as a Preventive Lifestyle Intervention Acts Through Specific Exosomal miRNA Species—Evidence From Human Short- and Long-Term Pilot Studies
por: Garai, Kitti, et al.
Publicado: (2021)

WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro
por: Zhang, Xiaonan, et al.
Publicado: (2022)

Artificial Neural Network Correlation and Biostatistics Evaluation of Physiological and Molecular Parameters in Healthy Young Individuals Performing Regular Exercise
por: Garai, Kitti, et al.
Publicado: (2019)

“Beige” Cross Talk Between the Immune System and Metabolism
por: Banfai, Krisztina, et al.
Publicado: (2019)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

An Essential Role for Medullary Thymic Epithelial Cells during the Intrathymic Development of Invariant NKT Cells
por: White, Andrea J., et al.
Publicado: (2014)

Wnt signalling in lung development and diseases
por: Pongracz, Judit E, et al.
Publicado: (2006)

Control of the thymic medulla and its influence on αβT‐cell development
por: Lucas, Beth, et al.
Publicado: (2016)

Natural Th17 cells are critically regulated by functional medullary thymic microenvironments
por: Jenkinson, William E., et al.
Publicado: (2015)

Osteoprotegerin-Mediated Homeostasis of Rank(+) Thymic Epithelial Cells Does Not Limit Foxp3(+) Regulatory T Cell Development
por: McCarthy, Nicholas I., et al.
Publicado: (2015)

Differential Requirement for Mesenchyme in the Proliferation and Maturation of Thymic Epithelial Progenitors
por: Jenkinson, William E., et al.
Publicado: (2003)

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
por: Lucas, Beth, et al.
Publicado: (2020)

Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis
por: Bartis, Domokos, et al.
Publicado: (2016)

Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility
por: Rapp, J., et al.
Publicado: (2016)

Thymic Atrophy and Apoptosis of CD4(+)CD8(+) Thymocytes in the Cuprizone Model of Multiple Sclerosis
por: Solti, Izabella, et al.
Publicado: (2015)

Effect of Bitis gabonica and Dendroaspis angusticeps snake venoms on apoptosis-related genes in human thymic epithelial cells
por: Boda, Francisc, et al.
Publicado: (2020)

The final lap…
por: Manohar, Balaji
Publicado: (2013)

Lap-Robotics
Publicado: (2015)

Normal T Cell Selection Occurs in CD205-Deficient Thymic Microenvironments
por: Jenkinson, William E., et al.
Publicado: (2012)

RANK signals from CD4(+)3(−) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
por: Rossi, Simona W., et al.
Publicado: (2007)

Effect of the Lapping Platen Groove Density on the Characteristics of Microabrasive-Based Lapping
por: Lee, Taekyung, et al.
Publicado: (2020)

Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
por: Roberts, Natalie A., et al.
Publicado: (2017)

Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors
por: Baik, Song, et al.
Publicado: (2013)

Serial progression of cortical and medullary thymic epithelial microenvironments
por: Alves, Nuno L, et al.
Publicado: (2014)

Signal processing with lapped transforms
por: Malvar, Henrique S
Publicado: (1992)

Pseudomonas putida Fis Binds to the lapF Promoter In Vitro and Represses the Expression of LapF
por: Lahesaare, Andrio, et al.
Publicado: (2014)

Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk
por: White, Andrea J., et al.
Publicado: (2023)

The Wnt Signaling Antagonist Kremen1 is Required for Development of Thymic Architecture
por: Osada, Masako, et al.
Publicado: (2006)

An Essential Role for Thymic Mesenchyme in Early T Cell Development
por: Suniara, Ravinder K., et al.
Publicado: (2000)

Applications of the Stochastic LapH Method
por: Bulava, John, et al.
Publicado: (2013)

Non-canonical autophagy LAPs lupus
por: Simon, A K, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ucgp1fhbuugoh7nuics61oar8q