Cargando…

Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level

BACKGROUND: The aim of this study was to investigate the effects of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass graft surgery (OPCAB) in patients with elevated serum high-sensitivity C-reactive protein (hs-CRP) levels. METHODS: Of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Young, Kwak, Young Lan, Choi, Yong Seon, Kim, Jong Chan, Heo, Sang Baek, Shim, Jae Kwang
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872864/
https://www.ncbi.nlm.nih.gov/pubmed/20498791
http://dx.doi.org/10.4097/kjae.2010.58.2.136
_version_ 1782181275365277696
author Song, Young
Kwak, Young Lan
Choi, Yong Seon
Kim, Jong Chan
Heo, Sang Baek
Shim, Jae Kwang
author_facet Song, Young
Kwak, Young Lan
Choi, Yong Seon
Kim, Jong Chan
Heo, Sang Baek
Shim, Jae Kwang
author_sort Song, Young
collection PubMed
description BACKGROUND: The aim of this study was to investigate the effects of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass graft surgery (OPCAB) in patients with elevated serum high-sensitivity C-reactive protein (hs-CRP) levels. METHODS: Of the 492 patients who underwent multivessel OPCAB from March 2007 to February 2009, the records of 144 patients whose baseline hs-CRP level > 2 mg/L were reviewed. According to the history of preoperative statin therapy for at least one week, patients were classified as either statin group or control group (72 subjects each). Preoperative and operative characteristics and postoperative data including troponin (Tn)-T level and major morbidity endpoints were obtained and compared. Major morbidity endpoints were defined as permanent stroke, renal dysfunction, hemostatic re-exploration, deep sternal wound infection, and the number of patients requiring prolonged ventilation. RESULTS: Preoperative and operative characteristics were similar between the two groups. There were no significant differences in the incidence of morbidity endpoints between the two groups, except for the number of patients requiring dialysis, which was significantly lower in the statin group (8 vs. 1, P = 0.033). Tn-T level at 24 h after surgery was also significantly lower in the statin group. CONCLUSIONS: In this study, we observed beneficial effects of preoperative statin therapy for at least one week in terms of less myocardial enzyme release and fewer patients requiring dialysis following OPCAB in patients whose preoperative hs-CRP was elevated.
format Text
id pubmed-2872864
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher The Korean Society of Anesthesiologists
record_format MEDLINE/PubMed
spelling pubmed-28728642010-05-24 Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level Song, Young Kwak, Young Lan Choi, Yong Seon Kim, Jong Chan Heo, Sang Baek Shim, Jae Kwang Korean J Anesthesiol Clinical Research Article BACKGROUND: The aim of this study was to investigate the effects of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass graft surgery (OPCAB) in patients with elevated serum high-sensitivity C-reactive protein (hs-CRP) levels. METHODS: Of the 492 patients who underwent multivessel OPCAB from March 2007 to February 2009, the records of 144 patients whose baseline hs-CRP level > 2 mg/L were reviewed. According to the history of preoperative statin therapy for at least one week, patients were classified as either statin group or control group (72 subjects each). Preoperative and operative characteristics and postoperative data including troponin (Tn)-T level and major morbidity endpoints were obtained and compared. Major morbidity endpoints were defined as permanent stroke, renal dysfunction, hemostatic re-exploration, deep sternal wound infection, and the number of patients requiring prolonged ventilation. RESULTS: Preoperative and operative characteristics were similar between the two groups. There were no significant differences in the incidence of morbidity endpoints between the two groups, except for the number of patients requiring dialysis, which was significantly lower in the statin group (8 vs. 1, P = 0.033). Tn-T level at 24 h after surgery was also significantly lower in the statin group. CONCLUSIONS: In this study, we observed beneficial effects of preoperative statin therapy for at least one week in terms of less myocardial enzyme release and fewer patients requiring dialysis following OPCAB in patients whose preoperative hs-CRP was elevated. The Korean Society of Anesthesiologists 2010-02 2010-02-28 /pmc/articles/PMC2872864/ /pubmed/20498791 http://dx.doi.org/10.4097/kjae.2010.58.2.136 Text en Copyright © The Korean Society of Anesthesiologists, 2010 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Song, Young
Kwak, Young Lan
Choi, Yong Seon
Kim, Jong Chan
Heo, Sang Baek
Shim, Jae Kwang
Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level
title Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level
title_full Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level
title_fullStr Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level
title_full_unstemmed Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level
title_short Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level
title_sort effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated c-reactive protein level
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872864/
https://www.ncbi.nlm.nih.gov/pubmed/20498791
http://dx.doi.org/10.4097/kjae.2010.58.2.136
work_keys_str_mv AT songyoung effectofpreoperativestatintherapyonmyocardialprotectionandmorbidityendpointsfollowingoffpumpcoronarybypasssurgeryinpatientswithelevatedcreactiveproteinlevel
AT kwakyounglan effectofpreoperativestatintherapyonmyocardialprotectionandmorbidityendpointsfollowingoffpumpcoronarybypasssurgeryinpatientswithelevatedcreactiveproteinlevel
AT choiyongseon effectofpreoperativestatintherapyonmyocardialprotectionandmorbidityendpointsfollowingoffpumpcoronarybypasssurgeryinpatientswithelevatedcreactiveproteinlevel
AT kimjongchan effectofpreoperativestatintherapyonmyocardialprotectionandmorbidityendpointsfollowingoffpumpcoronarybypasssurgeryinpatientswithelevatedcreactiveproteinlevel
AT heosangbaek effectofpreoperativestatintherapyonmyocardialprotectionandmorbidityendpointsfollowingoffpumpcoronarybypasssurgeryinpatientswithelevatedcreactiveproteinlevel
AT shimjaekwang effectofpreoperativestatintherapyonmyocardialprotectionandmorbidityendpointsfollowingoffpumpcoronarybypasssurgeryinpatientswithelevatedcreactiveproteinlevel