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The effect of ulinastatin on hemostasis in major orthopedic surgery
BACKGROUND: Ulinastatin, a urinary trypsin inhibitor, is widely used to treat acute systemic inflammatory disorders. However, the effects of ulinastatin, especially on the potential for hemostasis, have not been fully elucidated. This study examined whether ulinastatin had any beneficial effects on...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Society of Anesthesiologists
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872884/ https://www.ncbi.nlm.nih.gov/pubmed/20498808 http://dx.doi.org/10.4097/kjae.2010.58.1.25 |
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author | Lee, Jin Young Lee, Ji Young Chon, Jin Young Moon, Ho Sik Hong, Sung Jin |
author_facet | Lee, Jin Young Lee, Ji Young Chon, Jin Young Moon, Ho Sik Hong, Sung Jin |
author_sort | Lee, Jin Young |
collection | PubMed |
description | BACKGROUND: Ulinastatin, a urinary trypsin inhibitor, is widely used to treat acute systemic inflammatory disorders. However, the effects of ulinastatin, especially on the potential for hemostasis, have not been fully elucidated. This study examined whether ulinastatin had any beneficial effects on blood loss and blood transfusion requirements in patients undergoing major orthopedic surgery. METHODS: Eighty patients, aged 18 to 75 years, scheduled for major orthopedic surgery were enrolled in this study and were divided into the ulinastatin (n = 40) and control (n = 40) groups. Following the induction of general anesthesia, and immediately before the surgical incision, the patients in the ulinastatin group were given 5,000 units/kg of ulinastatin, which were mixed in 100 ml normal saline intravenously over 30 min, while those in the control group received the same volume of normal saline. The amounts of blood loss, infused fluid, and transfused blood products were measured throughout the study period. Blood samples for coagulation parameters were obtained before inducing anesthesia (T1), at the end of surgery (T2), and 12 h after surgery (T3). RESULTS: The amounts of blood loss and infused fluid during surgery were not significantly different between the two groups. However, 12 h postoperative blood loss was significantly less in the ulinastatin group than in the control group (255.0 ± 133.2 ml VS. 395.4 ± 338.4 ml, P < 0.05). CONCLUSIONS: Our data suggest that a single infusion of ulinastatin in major orthopedic surgery is associated with decreased blood loss in the early postoperative period. |
format | Text |
id | pubmed-2872884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Society of Anesthesiologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-28728842010-05-24 The effect of ulinastatin on hemostasis in major orthopedic surgery Lee, Jin Young Lee, Ji Young Chon, Jin Young Moon, Ho Sik Hong, Sung Jin Korean J Anesthesiol Clinical Research Article BACKGROUND: Ulinastatin, a urinary trypsin inhibitor, is widely used to treat acute systemic inflammatory disorders. However, the effects of ulinastatin, especially on the potential for hemostasis, have not been fully elucidated. This study examined whether ulinastatin had any beneficial effects on blood loss and blood transfusion requirements in patients undergoing major orthopedic surgery. METHODS: Eighty patients, aged 18 to 75 years, scheduled for major orthopedic surgery were enrolled in this study and were divided into the ulinastatin (n = 40) and control (n = 40) groups. Following the induction of general anesthesia, and immediately before the surgical incision, the patients in the ulinastatin group were given 5,000 units/kg of ulinastatin, which were mixed in 100 ml normal saline intravenously over 30 min, while those in the control group received the same volume of normal saline. The amounts of blood loss, infused fluid, and transfused blood products were measured throughout the study period. Blood samples for coagulation parameters were obtained before inducing anesthesia (T1), at the end of surgery (T2), and 12 h after surgery (T3). RESULTS: The amounts of blood loss and infused fluid during surgery were not significantly different between the two groups. However, 12 h postoperative blood loss was significantly less in the ulinastatin group than in the control group (255.0 ± 133.2 ml VS. 395.4 ± 338.4 ml, P < 0.05). CONCLUSIONS: Our data suggest that a single infusion of ulinastatin in major orthopedic surgery is associated with decreased blood loss in the early postoperative period. The Korean Society of Anesthesiologists 2010-01 2010-01-31 /pmc/articles/PMC2872884/ /pubmed/20498808 http://dx.doi.org/10.4097/kjae.2010.58.1.25 Text en Copyright © The Korean Society of Anesthesiologists, 2010 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Article Lee, Jin Young Lee, Ji Young Chon, Jin Young Moon, Ho Sik Hong, Sung Jin The effect of ulinastatin on hemostasis in major orthopedic surgery |
title | The effect of ulinastatin on hemostasis in major orthopedic surgery |
title_full | The effect of ulinastatin on hemostasis in major orthopedic surgery |
title_fullStr | The effect of ulinastatin on hemostasis in major orthopedic surgery |
title_full_unstemmed | The effect of ulinastatin on hemostasis in major orthopedic surgery |
title_short | The effect of ulinastatin on hemostasis in major orthopedic surgery |
title_sort | effect of ulinastatin on hemostasis in major orthopedic surgery |
topic | Clinical Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872884/ https://www.ncbi.nlm.nih.gov/pubmed/20498808 http://dx.doi.org/10.4097/kjae.2010.58.1.25 |
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