Metabolic oxidation regulates embryonic stem cell differentiation

Metabolites offer an important unexplored complement to understanding the pluripotency of stem cells. Using mass spectrometry-based metabolomics, we show that embryonic stem cells are characterized by abundant metabolites with highly unsaturated structures whose levels decrease upon differentiation....

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Detalles Bibliográficos
Autores principales: Yanes, Oscar, Clark, Julie, Wong, Diana M, Patti, Gary J, Sanchez-Ruiz, Antonio, Benton, H Paul, Trauger, Sunia A, Desponts, Caroline, Ding, Sheng, Siuzdak, Gary
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873061/
https://www.ncbi.nlm.nih.gov/pubmed/20436487
http://dx.doi.org/10.1038/nchembio.364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873061/
https://www.ncbi.nlm.nih.gov/pubmed/20436487
http://dx.doi.org/10.1038/nchembio.364

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