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Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation

BACKGROUND: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist. The mechanism of Xist RNA spreading and Xist-dependent silencing is poorly...

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Detalles Bibliográficos
Autores principales:	Tang, Y Amy, Huntley, Derek, Montana, Giovanni, Cerase, Andrea, Nesterova, Tatyana B, Brockdorff, Neil
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873326/ https://www.ncbi.nlm.nih.gov/pubmed/20459652 http://dx.doi.org/10.1186/1756-8935-3-10

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