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Metabolic engineering for the production of shikimic acid in an evolved Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system
BACKGROUND: Shikimic acid (SA) is utilized in the synthesis of oseltamivir-phosphate, an anti-influenza drug. In this work, metabolic engineering approaches were employed to produce SA in Escherichia coli strains derived from an evolved strain (PB12) lacking the phosphoenolpyruvate:carbohydrate phos...
Autores principales: | Escalante, Adelfo, Calderón, Rocío, Valdivia, Araceli, de Anda, Ramón, Hernández, Georgina, Ramírez, Octavio T, Gosset, Guillermo, Bolívar, Francisco |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873404/ https://www.ncbi.nlm.nih.gov/pubmed/20385022 http://dx.doi.org/10.1186/1475-2859-9-21 |
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