Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

BACKGROUND: Survivin is a dual functioning protein. It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. Since the molecular chaperone Hsp90 binds and stabilizes survivin, it is widely believed that down-re...

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Detalles Bibliográficos
Autores principales: Cheung, Chun Hei Antonio, Chen, Huang-Hui, Cheng, Li-Ting, Lyu, Kevin W, Kanwar, Jagat R, Chang, Jang-Yang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873435/
https://www.ncbi.nlm.nih.gov/pubmed/20398291
http://dx.doi.org/10.1186/1476-4598-9-77

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