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Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

BACKGROUND: Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 and Nrf2 transcription factors. In addition to effluxing chemotherapeutic drugs...

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Detalles Bibliográficos
Autores principales:	Suttana, Wipob, Mankhetkorn, Samlee, Poompimon, Wilart, Palagani, Ajay, Zhokhov, Sergey, Gerlo, Sarah, Haegeman, Guy, Berghe, Wim Vanden
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873443/ https://www.ncbi.nlm.nih.gov/pubmed/20438634 http://dx.doi.org/10.1186/1476-4598-9-99

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