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Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1maturation inhibitor bevirimat

BACKGROUND: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-1-infected patients do not respond to BVM. A...

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Detalles Bibliográficos
Autores principales:	Adamson, Catherine S, Sakalian, Michael, Salzwedel, Karl, Freed, Eric O
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873507/ https://www.ncbi.nlm.nih.gov/pubmed/20406463 http://dx.doi.org/10.1186/1742-4690-7-36

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