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Simulating gene-environment interactions in complex human diseases
Because little is currently known about how genes interact with environmental factors in human diseases, and because of the large number of possible interactions between and within genetic and environmental factors, it is difficult to simulate samples for a disease caused by multiple interacting gen...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873799/ https://www.ncbi.nlm.nih.gov/pubmed/20346093 http://dx.doi.org/10.1186/gm142 |
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author | Peng, Bo |
author_facet | Peng, Bo |
author_sort | Peng, Bo |
collection | PubMed |
description | Because little is currently known about how genes interact with environmental factors in human diseases, and because of the large number of possible interactions between and within genetic and environmental factors, it is difficult to simulate samples for a disease caused by multiple interacting genetic and environmental factors. A recent article by Amato and colleagues in BMC Bioinformatics describes a mathematical model to characterize gene-environment interactions and a computer program that simulates them using biologically meaningful inputs. Here, I evaluate the advantages and limitations of the authors' approach in terms of its usefulness for simulating genetic samples for real-world studies of gene-environment interactions in complex human diseases. |
format | Text |
id | pubmed-2873799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28737992011-03-23 Simulating gene-environment interactions in complex human diseases Peng, Bo Genome Med Minireview Because little is currently known about how genes interact with environmental factors in human diseases, and because of the large number of possible interactions between and within genetic and environmental factors, it is difficult to simulate samples for a disease caused by multiple interacting genetic and environmental factors. A recent article by Amato and colleagues in BMC Bioinformatics describes a mathematical model to characterize gene-environment interactions and a computer program that simulates them using biologically meaningful inputs. Here, I evaluate the advantages and limitations of the authors' approach in terms of its usefulness for simulating genetic samples for real-world studies of gene-environment interactions in complex human diseases. BioMed Central 2010-03-23 /pmc/articles/PMC2873799/ /pubmed/20346093 http://dx.doi.org/10.1186/gm142 Text en Copyright ©2010 BioMed Central Ltd. |
spellingShingle | Minireview Peng, Bo Simulating gene-environment interactions in complex human diseases |
title | Simulating gene-environment interactions in complex human diseases |
title_full | Simulating gene-environment interactions in complex human diseases |
title_fullStr | Simulating gene-environment interactions in complex human diseases |
title_full_unstemmed | Simulating gene-environment interactions in complex human diseases |
title_short | Simulating gene-environment interactions in complex human diseases |
title_sort | simulating gene-environment interactions in complex human diseases |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873799/ https://www.ncbi.nlm.nih.gov/pubmed/20346093 http://dx.doi.org/10.1186/gm142 |
work_keys_str_mv | AT pengbo simulatinggeneenvironmentinteractionsincomplexhumandiseases |