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Simulating gene-environment interactions in complex human diseases

Because little is currently known about how genes interact with environmental factors in human diseases, and because of the large number of possible interactions between and within genetic and environmental factors, it is difficult to simulate samples for a disease caused by multiple interacting gen...

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Detalles Bibliográficos
Autor principal: Peng, Bo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873799/
https://www.ncbi.nlm.nih.gov/pubmed/20346093
http://dx.doi.org/10.1186/gm142
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author Peng, Bo
author_facet Peng, Bo
author_sort Peng, Bo
collection PubMed
description Because little is currently known about how genes interact with environmental factors in human diseases, and because of the large number of possible interactions between and within genetic and environmental factors, it is difficult to simulate samples for a disease caused by multiple interacting genetic and environmental factors. A recent article by Amato and colleagues in BMC Bioinformatics describes a mathematical model to characterize gene-environment interactions and a computer program that simulates them using biologically meaningful inputs. Here, I evaluate the advantages and limitations of the authors' approach in terms of its usefulness for simulating genetic samples for real-world studies of gene-environment interactions in complex human diseases.
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spelling pubmed-28737992011-03-23 Simulating gene-environment interactions in complex human diseases Peng, Bo Genome Med Minireview Because little is currently known about how genes interact with environmental factors in human diseases, and because of the large number of possible interactions between and within genetic and environmental factors, it is difficult to simulate samples for a disease caused by multiple interacting genetic and environmental factors. A recent article by Amato and colleagues in BMC Bioinformatics describes a mathematical model to characterize gene-environment interactions and a computer program that simulates them using biologically meaningful inputs. Here, I evaluate the advantages and limitations of the authors' approach in terms of its usefulness for simulating genetic samples for real-world studies of gene-environment interactions in complex human diseases. BioMed Central 2010-03-23 /pmc/articles/PMC2873799/ /pubmed/20346093 http://dx.doi.org/10.1186/gm142 Text en Copyright ©2010 BioMed Central Ltd.
spellingShingle Minireview
Peng, Bo
Simulating gene-environment interactions in complex human diseases
title Simulating gene-environment interactions in complex human diseases
title_full Simulating gene-environment interactions in complex human diseases
title_fullStr Simulating gene-environment interactions in complex human diseases
title_full_unstemmed Simulating gene-environment interactions in complex human diseases
title_short Simulating gene-environment interactions in complex human diseases
title_sort simulating gene-environment interactions in complex human diseases
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873799/
https://www.ncbi.nlm.nih.gov/pubmed/20346093
http://dx.doi.org/10.1186/gm142
work_keys_str_mv AT pengbo simulatinggeneenvironmentinteractionsincomplexhumandiseases