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Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase, UTX, pointing to histone H3 lysine methylation deregulat...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873835/ https://www.ncbi.nlm.nih.gov/pubmed/19330029 http://dx.doi.org/10.1038/ng.349 |
| _version_ | 1782181404318105600 |
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| author | van Haaften, Gijs Dalgliesh, Gillian L Davies, Helen Chen, Lina Bignell, Graham Greenman, Chris Edkins, Sarah Hardy, Claire O’Meara, Sarah Teague, Jon Butler, Adam Hinton, Jonathan Latimer, Calli Andrews, Jenny Barthorpe, Syd Beare, Dave Buck, Gemma Campbell, Peter J Cole, Jennifer Dunmore, Rebecca Forbes, Simon Jia, Mingming Jones, David Kok, Chai Yin Leroy, Catherine Lin, Meng-Lay McBride, David J Maddison, Mark Maquire, Simon McLay, Kirsten Menzies, Andrew Mironenko, Tatiana Lee, Mulderrig Mudie, Laura Pleasance, Erin Shepherd, Rebecca Smith, Raffaella Stebbings, Lucy Stephens, Philip Tang, Gurpreet Tarpey, Patrick S Turner, Rachel Turrell, Kelly Varian, Jennifer West, Sofie Widaa, Sara Wray, Paul Collins, V Peter Ichimura, Koichi Law, Simon Wong, John Yuen, Siu Tsan Leung, Suet Yi Tonon, Giovanni DePinho, Ronald A Tai, Yu-Tzu Anderson, Kenneth C Kahnoski, Richard J. Massie, Aaron Khoo, Sok Kean Teh, Bin Tean Stratton, Michael R Futreal, P Andrew |
| author_facet | van Haaften, Gijs Dalgliesh, Gillian L Davies, Helen Chen, Lina Bignell, Graham Greenman, Chris Edkins, Sarah Hardy, Claire O’Meara, Sarah Teague, Jon Butler, Adam Hinton, Jonathan Latimer, Calli Andrews, Jenny Barthorpe, Syd Beare, Dave Buck, Gemma Campbell, Peter J Cole, Jennifer Dunmore, Rebecca Forbes, Simon Jia, Mingming Jones, David Kok, Chai Yin Leroy, Catherine Lin, Meng-Lay McBride, David J Maddison, Mark Maquire, Simon McLay, Kirsten Menzies, Andrew Mironenko, Tatiana Lee, Mulderrig Mudie, Laura Pleasance, Erin Shepherd, Rebecca Smith, Raffaella Stebbings, Lucy Stephens, Philip Tang, Gurpreet Tarpey, Patrick S Turner, Rachel Turrell, Kelly Varian, Jennifer West, Sofie Widaa, Sara Wray, Paul Collins, V Peter Ichimura, Koichi Law, Simon Wong, John Yuen, Siu Tsan Leung, Suet Yi Tonon, Giovanni DePinho, Ronald A Tai, Yu-Tzu Anderson, Kenneth C Kahnoski, Richard J. Massie, Aaron Khoo, Sok Kean Teh, Bin Tean Stratton, Michael R Futreal, P Andrew |
| author_sort | van Haaften, Gijs |
| collection | PubMed |
| description | Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase, UTX, pointing to histone H3 lysine methylation deregulation in multiple tumour types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene. |
| format | Text |
| id | pubmed-2873835 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28738352010-05-20 Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer van Haaften, Gijs Dalgliesh, Gillian L Davies, Helen Chen, Lina Bignell, Graham Greenman, Chris Edkins, Sarah Hardy, Claire O’Meara, Sarah Teague, Jon Butler, Adam Hinton, Jonathan Latimer, Calli Andrews, Jenny Barthorpe, Syd Beare, Dave Buck, Gemma Campbell, Peter J Cole, Jennifer Dunmore, Rebecca Forbes, Simon Jia, Mingming Jones, David Kok, Chai Yin Leroy, Catherine Lin, Meng-Lay McBride, David J Maddison, Mark Maquire, Simon McLay, Kirsten Menzies, Andrew Mironenko, Tatiana Lee, Mulderrig Mudie, Laura Pleasance, Erin Shepherd, Rebecca Smith, Raffaella Stebbings, Lucy Stephens, Philip Tang, Gurpreet Tarpey, Patrick S Turner, Rachel Turrell, Kelly Varian, Jennifer West, Sofie Widaa, Sara Wray, Paul Collins, V Peter Ichimura, Koichi Law, Simon Wong, John Yuen, Siu Tsan Leung, Suet Yi Tonon, Giovanni DePinho, Ronald A Tai, Yu-Tzu Anderson, Kenneth C Kahnoski, Richard J. Massie, Aaron Khoo, Sok Kean Teh, Bin Tean Stratton, Michael R Futreal, P Andrew Nat Genet Article Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase, UTX, pointing to histone H3 lysine methylation deregulation in multiple tumour types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene. 2009-03-29 2009-05 /pmc/articles/PMC2873835/ /pubmed/19330029 http://dx.doi.org/10.1038/ng.349 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article van Haaften, Gijs Dalgliesh, Gillian L Davies, Helen Chen, Lina Bignell, Graham Greenman, Chris Edkins, Sarah Hardy, Claire O’Meara, Sarah Teague, Jon Butler, Adam Hinton, Jonathan Latimer, Calli Andrews, Jenny Barthorpe, Syd Beare, Dave Buck, Gemma Campbell, Peter J Cole, Jennifer Dunmore, Rebecca Forbes, Simon Jia, Mingming Jones, David Kok, Chai Yin Leroy, Catherine Lin, Meng-Lay McBride, David J Maddison, Mark Maquire, Simon McLay, Kirsten Menzies, Andrew Mironenko, Tatiana Lee, Mulderrig Mudie, Laura Pleasance, Erin Shepherd, Rebecca Smith, Raffaella Stebbings, Lucy Stephens, Philip Tang, Gurpreet Tarpey, Patrick S Turner, Rachel Turrell, Kelly Varian, Jennifer West, Sofie Widaa, Sara Wray, Paul Collins, V Peter Ichimura, Koichi Law, Simon Wong, John Yuen, Siu Tsan Leung, Suet Yi Tonon, Giovanni DePinho, Ronald A Tai, Yu-Tzu Anderson, Kenneth C Kahnoski, Richard J. Massie, Aaron Khoo, Sok Kean Teh, Bin Tean Stratton, Michael R Futreal, P Andrew Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer |
| title | Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer |
| title_full | Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer |
| title_fullStr | Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer |
| title_full_unstemmed | Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer |
| title_short | Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer |
| title_sort | somatic mutations of the histone h3k27 demethylase, utx, in human cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873835/ https://www.ncbi.nlm.nih.gov/pubmed/19330029 http://dx.doi.org/10.1038/ng.349 |
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