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Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD

Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to A...

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Autores principales: Fennema-Notestine, Christine, McEvoy, Linda K., Hagler, Donald J., Jacobson, Mark W., Dale, Anders M., the Alzheimer’s Disease Neuroimaging Initiative
Formato: Texto
Lenguaje:English
Publicado: IOS Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873895/
https://www.ncbi.nlm.nih.gov/pubmed/19847040
http://dx.doi.org/10.3233/BEN-2009-0230
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author Fennema-Notestine, Christine
McEvoy, Linda K.
Hagler, Donald J.
Jacobson, Mark W.
Dale, Anders M.
the Alzheimer’s Disease Neuroimaging Initiative,
author_facet Fennema-Notestine, Christine
McEvoy, Linda K.
Hagler, Donald J.
Jacobson, Mark W.
Dale, Anders M.
the Alzheimer’s Disease Neuroimaging Initiative,
author_sort Fennema-Notestine, Christine
collection PubMed
description Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that measures of structural change in mesial and lateral temporal, cingulate, parietal and midfrontal areas may facilitate the assessment of a treatment's ability to halt the progressive structural loss that accompanies clinical decline in MCI. The performance of prediction is likely to continue to improve with the incorporation of measures from other neuroimaging modalities, clinical assessments, and neuromedical biomarkers, as the regional profile of individuals at risk for progression is refined.
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spelling pubmed-28738952010-05-20 Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD Fennema-Notestine, Christine McEvoy, Linda K. Hagler, Donald J. Jacobson, Mark W. Dale, Anders M. the Alzheimer’s Disease Neuroimaging Initiative, Behav Neurol Research Article Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that measures of structural change in mesial and lateral temporal, cingulate, parietal and midfrontal areas may facilitate the assessment of a treatment's ability to halt the progressive structural loss that accompanies clinical decline in MCI. The performance of prediction is likely to continue to improve with the incorporation of measures from other neuroimaging modalities, clinical assessments, and neuromedical biomarkers, as the regional profile of individuals at risk for progression is refined. IOS Press 2009 2009-10-21 /pmc/articles/PMC2873895/ /pubmed/19847040 http://dx.doi.org/10.3233/BEN-2009-0230 Text en Copyright © 2009 Hindawi Publishing Corporation and the authors. http://creativecommons.org/licenses/by/3.0 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fennema-Notestine, Christine
McEvoy, Linda K.
Hagler, Donald J.
Jacobson, Mark W.
Dale, Anders M.
the Alzheimer’s Disease Neuroimaging Initiative,
Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD
title Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD
title_full Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD
title_fullStr Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD
title_full_unstemmed Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD
title_short Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD
title_sort structural neuroimaging in the detection and prognosis of pre-clinical and early ad
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873895/
https://www.ncbi.nlm.nih.gov/pubmed/19847040
http://dx.doi.org/10.3233/BEN-2009-0230
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