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Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks

Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical...

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Autores principales: Audouze, Karine, Juncker, Agnieszka Sierakowska, Roque, Francisco J. S. S. A., Krysiak-Baltyn, Konrad, Weinhold, Nils, Taboureau, Olivier, Jensen, Thomas Skøt, Brunak, Søren
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873901/
https://www.ncbi.nlm.nih.gov/pubmed/20502671
http://dx.doi.org/10.1371/journal.pcbi.1000788
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author Audouze, Karine
Juncker, Agnieszka Sierakowska
Roque, Francisco J. S. S. A.
Krysiak-Baltyn, Konrad
Weinhold, Nils
Taboureau, Olivier
Jensen, Thomas Skøt
Brunak, Søren
author_facet Audouze, Karine
Juncker, Agnieszka Sierakowska
Roque, Francisco J. S. S. A.
Krysiak-Baltyn, Konrad
Weinhold, Nils
Taboureau, Olivier
Jensen, Thomas Skøt
Brunak, Søren
author_sort Audouze, Karine
collection PubMed
description Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical toxicology and systems biology. This computational systems chemical biology model reveals uncharacterized connections between compounds and diseases, thus predicting which compounds may be risk factors for human health. Additionally, the network can be used to identify unexpected potential associations between chemicals and proteins. Examples are shown for chemicals associated with breast cancer, lung cancer and necrosis, and potential protein targets for di-ethylhexyl-phthalate, 2,3,7,8-tetrachlorodibenzo-p-dioxin, pirinixic acid and permethrine. The chemical-protein associations are supported through recent published studies, which illustrate the power of our approach that integrates toxicogenomics data with other data types.
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spelling pubmed-28739012010-05-25 Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks Audouze, Karine Juncker, Agnieszka Sierakowska Roque, Francisco J. S. S. A. Krysiak-Baltyn, Konrad Weinhold, Nils Taboureau, Olivier Jensen, Thomas Skøt Brunak, Søren PLoS Comput Biol Research Article Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical toxicology and systems biology. This computational systems chemical biology model reveals uncharacterized connections between compounds and diseases, thus predicting which compounds may be risk factors for human health. Additionally, the network can be used to identify unexpected potential associations between chemicals and proteins. Examples are shown for chemicals associated with breast cancer, lung cancer and necrosis, and potential protein targets for di-ethylhexyl-phthalate, 2,3,7,8-tetrachlorodibenzo-p-dioxin, pirinixic acid and permethrine. The chemical-protein associations are supported through recent published studies, which illustrate the power of our approach that integrates toxicogenomics data with other data types. Public Library of Science 2010-05-20 /pmc/articles/PMC2873901/ /pubmed/20502671 http://dx.doi.org/10.1371/journal.pcbi.1000788 Text en Audouze et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Audouze, Karine
Juncker, Agnieszka Sierakowska
Roque, Francisco J. S. S. A.
Krysiak-Baltyn, Konrad
Weinhold, Nils
Taboureau, Olivier
Jensen, Thomas Skøt
Brunak, Søren
Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks
title Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks
title_full Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks
title_fullStr Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks
title_full_unstemmed Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks
title_short Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks
title_sort deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873901/
https://www.ncbi.nlm.nih.gov/pubmed/20502671
http://dx.doi.org/10.1371/journal.pcbi.1000788
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