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Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome

Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) encoding the Alzheimer's disease (AD) amyloid precursor protein (APP). Triplic...

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Detalles Bibliográficos
Autores principales:	Moncaster, Juliet A., Pineda, Roberto, Moir, Robert D., Lu, Suqian, Burton, Mark A., Ghosh, Joy G., Ericsson, Maria, Soscia, Stephanie J., Mocofanescu, Anca, Folkerth, Rebecca D., Robb, Richard M., Kuszak, Jer R., Clark, John I., Tanzi, Rudolph E., Hunter, David G., Goldstein, Lee E.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873949/ https://www.ncbi.nlm.nih.gov/pubmed/20502642 http://dx.doi.org/10.1371/journal.pone.0010659

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