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Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap”
Esophageal atresia and tracheoesophageal fistula (EA/TEF) are major congenital malformations affecting 1:3500 live births. Current research efforts are focused on understanding the etiology of these defects. We describe well-known animal models, human syndromes, and associations involving EA/TEF, in...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Current Science Inc.
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874026/ https://www.ncbi.nlm.nih.gov/pubmed/20425471 http://dx.doi.org/10.1007/s11894-010-0108-1 |
Sumario: | Esophageal atresia and tracheoesophageal fistula (EA/TEF) are major congenital malformations affecting 1:3500 live births. Current research efforts are focused on understanding the etiology of these defects. We describe well-known animal models, human syndromes, and associations involving EA/TEF, indicating its etiologically heterogeneous nature. Recent advances in genotyping technology and in knowledge of human genetic variation will improve clinical counseling on etiologic factors. This review provides a clinical summary of environmental and genetic factors involved in EA/TEF. |
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