Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap”

Esophageal atresia and tracheoesophageal fistula (EA/TEF) are major congenital malformations affecting 1:3500 live births. Current research efforts are focused on understanding the etiology of these defects. We describe well-known animal models, human syndromes, and associations involving EA/TEF, in...

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Autores principales: de Jong, Elisabeth M., Felix, Janine F., de Klein, Annelies, Tibboel, Dick
Formato: Texto
Lenguaje:English
Publicado: Current Science Inc. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874026/
https://www.ncbi.nlm.nih.gov/pubmed/20425471
http://dx.doi.org/10.1007/s11894-010-0108-1
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author de Jong, Elisabeth M.
Felix, Janine F.
de Klein, Annelies
Tibboel, Dick
author_facet de Jong, Elisabeth M.
Felix, Janine F.
de Klein, Annelies
Tibboel, Dick
author_sort de Jong, Elisabeth M.
collection PubMed
description Esophageal atresia and tracheoesophageal fistula (EA/TEF) are major congenital malformations affecting 1:3500 live births. Current research efforts are focused on understanding the etiology of these defects. We describe well-known animal models, human syndromes, and associations involving EA/TEF, indicating its etiologically heterogeneous nature. Recent advances in genotyping technology and in knowledge of human genetic variation will improve clinical counseling on etiologic factors. This review provides a clinical summary of environmental and genetic factors involved in EA/TEF.
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spelling pubmed-28740262010-06-04 Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap” de Jong, Elisabeth M. Felix, Janine F. de Klein, Annelies Tibboel, Dick Curr Gastroenterol Rep Article Esophageal atresia and tracheoesophageal fistula (EA/TEF) are major congenital malformations affecting 1:3500 live births. Current research efforts are focused on understanding the etiology of these defects. We describe well-known animal models, human syndromes, and associations involving EA/TEF, indicating its etiologically heterogeneous nature. Recent advances in genotyping technology and in knowledge of human genetic variation will improve clinical counseling on etiologic factors. This review provides a clinical summary of environmental and genetic factors involved in EA/TEF. Current Science Inc. 2010-04-28 2010 /pmc/articles/PMC2874026/ /pubmed/20425471 http://dx.doi.org/10.1007/s11894-010-0108-1 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
de Jong, Elisabeth M.
Felix, Janine F.
de Klein, Annelies
Tibboel, Dick
Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap”
title Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap”
title_full Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap”
title_fullStr Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap”
title_full_unstemmed Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap”
title_short Etiology of Esophageal Atresia and Tracheoesophageal Fistula: “Mind the Gap”
title_sort etiology of esophageal atresia and tracheoesophageal fistula: “mind the gap”
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874026/
https://www.ncbi.nlm.nih.gov/pubmed/20425471
http://dx.doi.org/10.1007/s11894-010-0108-1
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AT felixjaninef etiologyofesophagealatresiaandtracheoesophagealfistulamindthegap
AT dekleinannelies etiologyofesophagealatresiaandtracheoesophagealfistulamindthegap
AT tibboeldick etiologyofesophagealatresiaandtracheoesophagealfistulamindthegap

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