PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

Memory B and plasma cells (PCs) are generated in the germinal center (GC). As PD-1 is highly expressed in T follicular helper cells (T(FH)), we investigated the role of PD-1 signaling in the humoral response. We found that PD-L1 and PD-L2 are upregulated on GC B cells. Pdcd1lg2(−/−), CD274(−/−)Pdcd1...

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Detalles Bibliográficos
Autores principales: Good-Jacobson, Kim L., Szumilas, Courtney G., Chen, Lieping, Sharpe, Arlene H., Tomayko, Mary M., Shlomchik, Mark J.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874069/
https://www.ncbi.nlm.nih.gov/pubmed/20453843
http://dx.doi.org/10.1038/ni.1877

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