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Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

BACKGROUND: Alzheimer's disease (AD) and a host of other neurodegenerative central nervous system (CNS) proteinopathies are characterized by the accumulation of misfolded protein aggregates. Simplistically, these aggregates can be divided into smaller, soluble, oligomeric and larger, less-solub...

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Detalles Bibliográficos
Autores principales:	Golde, Todd E, Miller, Victor M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874257/ https://www.ncbi.nlm.nih.gov/pubmed/19822029 http://dx.doi.org/10.1186/alzrt5

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