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Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties
[Image: see text] 3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure−activity relationships of analogues of these inhibitor...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874265/ https://www.ncbi.nlm.nih.gov/pubmed/20426423 http://dx.doi.org/10.1021/jm9016366 |
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| author | Haydon, David J. Bennett, James M. Brown, David Collins, Ian Galbraith, Greta Lancett, Paul Macdonald, Rebecca Stokes, Neil R. Chauhan, Pramod K. Sutariya, Jignesh K. Nayal, Narendra Srivastava, Anil Beanland, Joy Hall, Robin Henstock, Vincent Noula, Caterina Rockley, Chris Czaplewski, Lloyd |
| author_facet | Haydon, David J. Bennett, James M. Brown, David Collins, Ian Galbraith, Greta Lancett, Paul Macdonald, Rebecca Stokes, Neil R. Chauhan, Pramod K. Sutariya, Jignesh K. Nayal, Narendra Srivastava, Anil Beanland, Joy Hall, Robin Henstock, Vincent Noula, Caterina Rockley, Chris Czaplewski, Lloyd |
| author_sort | Haydon, David J. |
| collection | PubMed |
| description | [Image: see text] 3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure−activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties. |
| format | Text |
| id | pubmed-2874265 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28742652010-05-21 Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties Haydon, David J. Bennett, James M. Brown, David Collins, Ian Galbraith, Greta Lancett, Paul Macdonald, Rebecca Stokes, Neil R. Chauhan, Pramod K. Sutariya, Jignesh K. Nayal, Narendra Srivastava, Anil Beanland, Joy Hall, Robin Henstock, Vincent Noula, Caterina Rockley, Chris Czaplewski, Lloyd J Med Chem [Image: see text] 3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure−activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties. American Chemical Society 2010-04-28 2010-05-27 /pmc/articles/PMC2874265/ /pubmed/20426423 http://dx.doi.org/10.1021/jm9016366 Text en Copyright © 2010 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org. |
| spellingShingle | Haydon, David J. Bennett, James M. Brown, David Collins, Ian Galbraith, Greta Lancett, Paul Macdonald, Rebecca Stokes, Neil R. Chauhan, Pramod K. Sutariya, Jignesh K. Nayal, Narendra Srivastava, Anil Beanland, Joy Hall, Robin Henstock, Vincent Noula, Caterina Rockley, Chris Czaplewski, Lloyd Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties |
| title | Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties |
| title_full | Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties |
| title_fullStr | Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties |
| title_full_unstemmed | Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties |
| title_short | Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties |
| title_sort | creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein ftsz with improved pharmaceutical properties |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874265/ https://www.ncbi.nlm.nih.gov/pubmed/20426423 http://dx.doi.org/10.1021/jm9016366 |
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