Colloid Formation by Drugs in Simulated Intestinal Fluid

[Image: see text] Many organic molecules form colloidal aggregates in aqueous solution at micromolar concentrations. These aggregates promiscuously inhibit soluble proteins and are a major source of false positives in high-throughput screening. Several drugs also form colloidal aggregates, and there...

Descripción completa

Detalles Bibliográficos
Autores principales: Doak, Allison K., Wille, Holger, Prusiner, Stanley B., Shoichet, Brian K.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874266/
https://www.ncbi.nlm.nih.gov/pubmed/20426472
http://dx.doi.org/10.1021/jm100254w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874266/
https://www.ncbi.nlm.nih.gov/pubmed/20426472
http://dx.doi.org/10.1021/jm100254w

Ejemplares similares