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Colloid Formation by Drugs in Simulated Intestinal Fluid
[Image: see text] Many organic molecules form colloidal aggregates in aqueous solution at micromolar concentrations. These aggregates promiscuously inhibit soluble proteins and are a major source of false positives in high-throughput screening. Several drugs also form colloidal aggregates, and there...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874266/ https://www.ncbi.nlm.nih.gov/pubmed/20426472 http://dx.doi.org/10.1021/jm100254w |