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Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia

In July 2007, a cluster of meningitis cases caused by an echovirus 4 strain was detected in 1 indigenous community in the Top End of the Northern Territory of Australia. Illness was characterized by fever, vomiting, and headache. Over the next 4 months, additional cases of meningitis and the fever a...

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Autores principales: Markey, Peter G., Davis, Joshua S., Harnett, Gerry B., Williams, Simon H., Speers, David J.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874345/
https://www.ncbi.nlm.nih.gov/pubmed/20031044
http://dx.doi.org/10.3201/eid1601.081519
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author Markey, Peter G.
Davis, Joshua S.
Harnett, Gerry B.
Williams, Simon H.
Speers, David J.
author_facet Markey, Peter G.
Davis, Joshua S.
Harnett, Gerry B.
Williams, Simon H.
Speers, David J.
author_sort Markey, Peter G.
collection PubMed
description In July 2007, a cluster of meningitis cases caused by an echovirus 4 strain was detected in 1 indigenous community in the Top End of the Northern Territory of Australia. Illness was characterized by fever, vomiting, and headache. Over the next 4 months, additional cases of meningitis and the fever and vomiting syndrome emerged in other indigenous communities and subsequently in the major urban center of Darwin. We describe the epidemiology of 95 laboratory-confirmed meningitis cases and conclude that the epidemic fever and vomiting syndrome was caused by the same enterovirus. Nucleotide sequencing of the whole genome verified this enterovirus (AUS250G) as a strain of echovirus type 4. Viral protein 1 nucleotide sequencing demonstrated 96% homology with an echovirus 4 strain responsible for a large outbreak of meningitis in the Yanbian Prefecture of China in 1996.
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spelling pubmed-28743452010-05-26 Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia Markey, Peter G. Davis, Joshua S. Harnett, Gerry B. Williams, Simon H. Speers, David J. Emerg Infect Dis Research In July 2007, a cluster of meningitis cases caused by an echovirus 4 strain was detected in 1 indigenous community in the Top End of the Northern Territory of Australia. Illness was characterized by fever, vomiting, and headache. Over the next 4 months, additional cases of meningitis and the fever and vomiting syndrome emerged in other indigenous communities and subsequently in the major urban center of Darwin. We describe the epidemiology of 95 laboratory-confirmed meningitis cases and conclude that the epidemic fever and vomiting syndrome was caused by the same enterovirus. Nucleotide sequencing of the whole genome verified this enterovirus (AUS250G) as a strain of echovirus type 4. Viral protein 1 nucleotide sequencing demonstrated 96% homology with an echovirus 4 strain responsible for a large outbreak of meningitis in the Yanbian Prefecture of China in 1996. Centers for Disease Control and Prevention 2010-01 /pmc/articles/PMC2874345/ /pubmed/20031044 http://dx.doi.org/10.3201/eid1601.081519 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Markey, Peter G.
Davis, Joshua S.
Harnett, Gerry B.
Williams, Simon H.
Speers, David J.
Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia
title Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia
title_full Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia
title_fullStr Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia
title_full_unstemmed Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia
title_short Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia
title_sort meningitis and a febrile vomiting illness caused by echovirus type 4, northern territory, australia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874345/
https://www.ncbi.nlm.nih.gov/pubmed/20031044
http://dx.doi.org/10.3201/eid1601.081519
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