Acute Encephalopathy Associated with Influenza A Infection in Adults

We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios >3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered w...

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Detalles Bibliográficos
Autores principales: Lee, Nelson, Wong, Chun Kwok, Chan, Paul K.S., Lindegardh, Niklas, White, Nicholas J., Hayden, Frederick G., Wong, Edward H.C., Wong, Ka Shing, Cockram, Clive S., Sung, Joseph J.Y., Hui, David S.C.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2010
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874350/
https://www.ncbi.nlm.nih.gov/pubmed/20031062
http://dx.doi.org/10.3201/eid1601.090077
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author Lee, Nelson
Wong, Chun Kwok
Chan, Paul K.S.
Lindegardh, Niklas
White, Nicholas J.
Hayden, Frederick G.
Wong, Edward H.C.
Wong, Ka Shing
Cockram, Clive S.
Sung, Joseph J.Y.
Hui, David S.C.
author_facet Lee, Nelson
Wong, Chun Kwok
Chan, Paul K.S.
Lindegardh, Niklas
White, Nicholas J.
Hayden, Frederick G.
Wong, Edward H.C.
Wong, Ka Shing
Cockram, Clive S.
Sung, Joseph J.Y.
Hui, David S.C.
author_sort Lee, Nelson
collection PubMed
description We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios >3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.
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spelling pubmed-28743502010-05-26 Acute Encephalopathy Associated with Influenza A Infection in Adults Lee, Nelson Wong, Chun Kwok Chan, Paul K.S. Lindegardh, Niklas White, Nicholas J. Hayden, Frederick G. Wong, Edward H.C. Wong, Ka Shing Cockram, Clive S. Sung, Joseph J.Y. Hui, David S.C. Emerg Infect Dis Dispatch We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios >3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis. Centers for Disease Control and Prevention 2010-01 /pmc/articles/PMC2874350/ /pubmed/20031062 http://dx.doi.org/10.3201/eid1601.090077 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Lee, Nelson
Wong, Chun Kwok
Chan, Paul K.S.
Lindegardh, Niklas
White, Nicholas J.
Hayden, Frederick G.
Wong, Edward H.C.
Wong, Ka Shing
Cockram, Clive S.
Sung, Joseph J.Y.
Hui, David S.C.
Acute Encephalopathy Associated with Influenza A Infection in Adults
title Acute Encephalopathy Associated with Influenza A Infection in Adults
title_full Acute Encephalopathy Associated with Influenza A Infection in Adults
title_fullStr Acute Encephalopathy Associated with Influenza A Infection in Adults
title_full_unstemmed Acute Encephalopathy Associated with Influenza A Infection in Adults
title_short Acute Encephalopathy Associated with Influenza A Infection in Adults
title_sort acute encephalopathy associated with influenza a infection in adults
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874350/
https://www.ncbi.nlm.nih.gov/pubmed/20031062
http://dx.doi.org/10.3201/eid1601.090077
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