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Human herpesvirus 6 infection impairs Toll-like receptor signaling
Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an important role in innate immunity against var...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874541/ https://www.ncbi.nlm.nih.gov/pubmed/20459723 http://dx.doi.org/10.1186/1743-422X-7-91 |
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author | Murakami, Yuichi Tanimoto, Kazushi Fujiwara, Hiroshi An, Jun Suemori, Koichiro Ochi, Toshiki Hasegawa, Hitoshi Yasukawa, Masaki |
author_facet | Murakami, Yuichi Tanimoto, Kazushi Fujiwara, Hiroshi An, Jun Suemori, Koichiro Ochi, Toshiki Hasegawa, Hitoshi Yasukawa, Masaki |
author_sort | Murakami, Yuichi |
collection | PubMed |
description | Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an important role in innate immunity against various pathogens. In the present study, we investigated the effect of HHV-6 infection on the expression and intracellular signaling of TLRs in DCs. Although expression levels of TLRs were not decreased or slightly elevated following HHV-6 infection, the amounts of cytokines produced following stimulation with ligands for TLRs appeared to be dramatically decreased in HHV-6-infected DCs as compared to mock-infected DCs. Similarly, phosphorylation levels of TAK-1, IκB kinase, and IκB-α following stimulation of HHV-6-infected DCs with lipopolysaccharide, which is the ligand for TLR4, appeared to be decreased. These data show that HHV-6 impairs intracellular signaling through TLRs indicating the novel mechanism of HHV-6-mediated immunomodulation. |
format | Text |
id | pubmed-2874541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28745412010-05-22 Human herpesvirus 6 infection impairs Toll-like receptor signaling Murakami, Yuichi Tanimoto, Kazushi Fujiwara, Hiroshi An, Jun Suemori, Koichiro Ochi, Toshiki Hasegawa, Hitoshi Yasukawa, Masaki Virol J Short Report Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an important role in innate immunity against various pathogens. In the present study, we investigated the effect of HHV-6 infection on the expression and intracellular signaling of TLRs in DCs. Although expression levels of TLRs were not decreased or slightly elevated following HHV-6 infection, the amounts of cytokines produced following stimulation with ligands for TLRs appeared to be dramatically decreased in HHV-6-infected DCs as compared to mock-infected DCs. Similarly, phosphorylation levels of TAK-1, IκB kinase, and IκB-α following stimulation of HHV-6-infected DCs with lipopolysaccharide, which is the ligand for TLR4, appeared to be decreased. These data show that HHV-6 impairs intracellular signaling through TLRs indicating the novel mechanism of HHV-6-mediated immunomodulation. BioMed Central 2010-05-10 /pmc/articles/PMC2874541/ /pubmed/20459723 http://dx.doi.org/10.1186/1743-422X-7-91 Text en Copyright ©2010 Murakami et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Murakami, Yuichi Tanimoto, Kazushi Fujiwara, Hiroshi An, Jun Suemori, Koichiro Ochi, Toshiki Hasegawa, Hitoshi Yasukawa, Masaki Human herpesvirus 6 infection impairs Toll-like receptor signaling |
title | Human herpesvirus 6 infection impairs Toll-like receptor signaling |
title_full | Human herpesvirus 6 infection impairs Toll-like receptor signaling |
title_fullStr | Human herpesvirus 6 infection impairs Toll-like receptor signaling |
title_full_unstemmed | Human herpesvirus 6 infection impairs Toll-like receptor signaling |
title_short | Human herpesvirus 6 infection impairs Toll-like receptor signaling |
title_sort | human herpesvirus 6 infection impairs toll-like receptor signaling |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874541/ https://www.ncbi.nlm.nih.gov/pubmed/20459723 http://dx.doi.org/10.1186/1743-422X-7-91 |
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