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Imatinib-resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprogramming

As chronic myeloid leukemia (CML) progresses from the chronic phase to blast crisis, the levels of BCR-ABL increase. In addition, blast transformed leukemic cells display enhanced resistance to imatinib in the absence of BCR-ABL resistance mutations. Here we show that when BCR-ABL transformed cell l...

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Detalles Bibliográficos
Autores principales:	Zhao, Fangping, Mancuso, Anthony, Bui, Thi V., Tong, Xuemei, Gruber, Joshua J., Swider, Cezary R., Sanchez, Patricia V, Lum, Julian J., Sayed, Nabil, Melo, Junia V., Perl, Alexander E., Carroll, Martin, Tuttle, Stephen W., Thompson, Craig B.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874611/ https://www.ncbi.nlm.nih.gov/pubmed/20228846 http://dx.doi.org/10.1038/onc.2010.67

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