The role of mitochondria in the mammalian antiviral defense system

Innate immunity is a crucial defense system against viral and bacterial pathogens, providing a rapid response to mitigate the effects of microbial attack. While more readily associated with respiration and metabolism, recent research has surprisingly identified a number of mitochondrial factors in t...

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Detalles Bibliográficos
Autor principal: Scott, Iain
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874622/
https://www.ncbi.nlm.nih.gov/pubmed/20206303
http://dx.doi.org/10.1016/j.mito.2010.02.005
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author Scott, Iain
author_facet Scott, Iain
author_sort Scott, Iain
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description Innate immunity is a crucial defense system against viral and bacterial pathogens, providing a rapid response to mitigate the effects of microbial attack. While more readily associated with respiration and metabolism, recent research has surprisingly identified a number of mitochondrial factors in the mammalian innate immune system. This review summarizes the novel mitochondrial proteins, such as MAVS and NLRX1, involved in this process and attempts to reconcile this new mitochondrial function with our previous knowledge of the organelle.
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spelling pubmed-28746222011-06-01 The role of mitochondria in the mammalian antiviral defense system Scott, Iain Mitochondrion Article Innate immunity is a crucial defense system against viral and bacterial pathogens, providing a rapid response to mitigate the effects of microbial attack. While more readily associated with respiration and metabolism, recent research has surprisingly identified a number of mitochondrial factors in the mammalian innate immune system. This review summarizes the novel mitochondrial proteins, such as MAVS and NLRX1, involved in this process and attempts to reconcile this new mitochondrial function with our previous knowledge of the organelle. Elsevier Science 2010-06 2010-03-02 /pmc/articles/PMC2874622/ /pubmed/20206303 http://dx.doi.org/10.1016/j.mito.2010.02.005 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Scott, Iain
The role of mitochondria in the mammalian antiviral defense system
title The role of mitochondria in the mammalian antiviral defense system
title_full The role of mitochondria in the mammalian antiviral defense system
title_fullStr The role of mitochondria in the mammalian antiviral defense system
title_full_unstemmed The role of mitochondria in the mammalian antiviral defense system
title_short The role of mitochondria in the mammalian antiviral defense system
title_sort role of mitochondria in the mammalian antiviral defense system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874622/
https://www.ncbi.nlm.nih.gov/pubmed/20206303
http://dx.doi.org/10.1016/j.mito.2010.02.005
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