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Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

OBJECTIVE: Thioredoxin interacting protein (Txnip), a regulator of cellular oxidative stress, is induced by hyperglycemia and inhibits glucose uptake into fat and muscle, suggesting a role for Txnip in type 2 diabetes pathogenesis. Here, we tested the hypothesis that Txnip-null (knockout) mice are p...

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Detalles Bibliográficos
Autores principales:	Chutkow, William A., Birkenfeld, Andreas L., Brown, Jonathan D., Lee, Hui-Young, Frederick, David W., Yoshioka, Jun, Patwari, Parth, Kursawe, Romy, Cushman, Samuel W., Plutzky, Jorge, Shulman, Gerald I., Samuel, Varman T., Lee, Richard T.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874703/ https://www.ncbi.nlm.nih.gov/pubmed/20299477 http://dx.doi.org/10.2337/db09-1212

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