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Henoch-Schonlein Purpura—A Case Report and Review of the Literature
We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointesti...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874920/ https://www.ncbi.nlm.nih.gov/pubmed/20508739 http://dx.doi.org/10.1155/2010/597648 |
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author | Sohagia, Amit B. Gunturu, Srinivas Guptha Tong, Tommy R. Hertan, Hilary I. |
author_facet | Sohagia, Amit B. Gunturu, Srinivas Guptha Tong, Tommy R. Hertan, Hilary I. |
author_sort | Sohagia, Amit B. |
collection | PubMed |
description | We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage. |
format | Text |
id | pubmed-2874920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28749202010-05-27 Henoch-Schonlein Purpura—A Case Report and Review of the Literature Sohagia, Amit B. Gunturu, Srinivas Guptha Tong, Tommy R. Hertan, Hilary I. Gastroenterol Res Pract Case Report We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage. Hindawi Publishing Corporation 2010 2010-05-23 /pmc/articles/PMC2874920/ /pubmed/20508739 http://dx.doi.org/10.1155/2010/597648 Text en Copyright © 2010 Amit B. Sohagia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sohagia, Amit B. Gunturu, Srinivas Guptha Tong, Tommy R. Hertan, Hilary I. Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
title | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
title_full | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
title_fullStr | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
title_full_unstemmed | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
title_short | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
title_sort | henoch-schonlein purpura—a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874920/ https://www.ncbi.nlm.nih.gov/pubmed/20508739 http://dx.doi.org/10.1155/2010/597648 |
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