Cargando…

Henoch-Schonlein Purpura—A Case Report and Review of the Literature

We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointesti...

Descripción completa

Detalles Bibliográficos
Autores principales: Sohagia, Amit B., Gunturu, Srinivas Guptha, Tong, Tommy R., Hertan, Hilary I.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874920/
https://www.ncbi.nlm.nih.gov/pubmed/20508739
http://dx.doi.org/10.1155/2010/597648
_version_ 1782181526208774144
author Sohagia, Amit B.
Gunturu, Srinivas Guptha
Tong, Tommy R.
Hertan, Hilary I.
author_facet Sohagia, Amit B.
Gunturu, Srinivas Guptha
Tong, Tommy R.
Hertan, Hilary I.
author_sort Sohagia, Amit B.
collection PubMed
description We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage.
format Text
id pubmed-2874920
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-28749202010-05-27 Henoch-Schonlein Purpura—A Case Report and Review of the Literature Sohagia, Amit B. Gunturu, Srinivas Guptha Tong, Tommy R. Hertan, Hilary I. Gastroenterol Res Pract Case Report We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage. Hindawi Publishing Corporation 2010 2010-05-23 /pmc/articles/PMC2874920/ /pubmed/20508739 http://dx.doi.org/10.1155/2010/597648 Text en Copyright © 2010 Amit B. Sohagia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sohagia, Amit B.
Gunturu, Srinivas Guptha
Tong, Tommy R.
Hertan, Hilary I.
Henoch-Schonlein Purpura—A Case Report and Review of the Literature
title Henoch-Schonlein Purpura—A Case Report and Review of the Literature
title_full Henoch-Schonlein Purpura—A Case Report and Review of the Literature
title_fullStr Henoch-Schonlein Purpura—A Case Report and Review of the Literature
title_full_unstemmed Henoch-Schonlein Purpura—A Case Report and Review of the Literature
title_short Henoch-Schonlein Purpura—A Case Report and Review of the Literature
title_sort henoch-schonlein purpura—a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874920/
https://www.ncbi.nlm.nih.gov/pubmed/20508739
http://dx.doi.org/10.1155/2010/597648
work_keys_str_mv AT sohagiaamitb henochschonleinpurpuraacasereportandreviewoftheliterature
AT gunturusrinivasguptha henochschonleinpurpuraacasereportandreviewoftheliterature
AT tongtommyr henochschonleinpurpuraacasereportandreviewoftheliterature
AT hertanhilaryi henochschonleinpurpuraacasereportandreviewoftheliterature