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Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection

Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to activ...

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Autores principales: Hiroishi, Kazumasa, Eguchi, Junichi, Ishii, Shigeaki, Hiraide, Ayako, Sakaki, Masashi, Doi, Hiroyoshi, Omori, Risa, Imawari, Michio
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874944/
https://www.ncbi.nlm.nih.gov/pubmed/20508848
http://dx.doi.org/10.1155/2010/263810
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author Hiroishi, Kazumasa
Eguchi, Junichi
Ishii, Shigeaki
Hiraide, Ayako
Sakaki, Masashi
Doi, Hiroyoshi
Omori, Risa
Imawari, Michio
author_facet Hiroishi, Kazumasa
Eguchi, Junichi
Ishii, Shigeaki
Hiraide, Ayako
Sakaki, Masashi
Doi, Hiroyoshi
Omori, Risa
Imawari, Michio
author_sort Hiroishi, Kazumasa
collection PubMed
description Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs. Induction of a strong HCV-specific CTL response in HCV-infected patients can facilitate complete HCV clearance. Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected. We investigated HCV-specific CTL responses by enzyme-linked immuno-spot assay and/or synthetic peptides and identified over 40 novel CTL epitopes in the HCV protein. Our findings may contribute to the development of the HCV vaccine. In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles.
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spelling pubmed-28749442010-05-27 Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection Hiroishi, Kazumasa Eguchi, Junichi Ishii, Shigeaki Hiraide, Ayako Sakaki, Masashi Doi, Hiroyoshi Omori, Risa Imawari, Michio J Biomed Biotechnol Review Article Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs. Induction of a strong HCV-specific CTL response in HCV-infected patients can facilitate complete HCV clearance. Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected. We investigated HCV-specific CTL responses by enzyme-linked immuno-spot assay and/or synthetic peptides and identified over 40 novel CTL epitopes in the HCV protein. Our findings may contribute to the development of the HCV vaccine. In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles. Hindawi Publishing Corporation 2010 2010-05-20 /pmc/articles/PMC2874944/ /pubmed/20508848 http://dx.doi.org/10.1155/2010/263810 Text en Copyright © 2010 Kazumasa Hiroishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hiroishi, Kazumasa
Eguchi, Junichi
Ishii, Shigeaki
Hiraide, Ayako
Sakaki, Masashi
Doi, Hiroyoshi
Omori, Risa
Imawari, Michio
Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
title Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
title_full Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
title_fullStr Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
title_full_unstemmed Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
title_short Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
title_sort immune response of cytotoxic t lymphocytes and possibility of vaccine development for hepatitis c virus infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874944/
https://www.ncbi.nlm.nih.gov/pubmed/20508848
http://dx.doi.org/10.1155/2010/263810
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