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Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to activ...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874944/ https://www.ncbi.nlm.nih.gov/pubmed/20508848 http://dx.doi.org/10.1155/2010/263810 |
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author | Hiroishi, Kazumasa Eguchi, Junichi Ishii, Shigeaki Hiraide, Ayako Sakaki, Masashi Doi, Hiroyoshi Omori, Risa Imawari, Michio |
author_facet | Hiroishi, Kazumasa Eguchi, Junichi Ishii, Shigeaki Hiraide, Ayako Sakaki, Masashi Doi, Hiroyoshi Omori, Risa Imawari, Michio |
author_sort | Hiroishi, Kazumasa |
collection | PubMed |
description | Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs. Induction of a strong HCV-specific CTL response in HCV-infected patients can facilitate complete HCV clearance. Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected. We investigated HCV-specific CTL responses by enzyme-linked immuno-spot assay and/or synthetic peptides and identified over 40 novel CTL epitopes in the HCV protein. Our findings may contribute to the development of the HCV vaccine. In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles. |
format | Text |
id | pubmed-2874944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28749442010-05-27 Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection Hiroishi, Kazumasa Eguchi, Junichi Ishii, Shigeaki Hiraide, Ayako Sakaki, Masashi Doi, Hiroyoshi Omori, Risa Imawari, Michio J Biomed Biotechnol Review Article Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs. Induction of a strong HCV-specific CTL response in HCV-infected patients can facilitate complete HCV clearance. Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected. We investigated HCV-specific CTL responses by enzyme-linked immuno-spot assay and/or synthetic peptides and identified over 40 novel CTL epitopes in the HCV protein. Our findings may contribute to the development of the HCV vaccine. In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles. Hindawi Publishing Corporation 2010 2010-05-20 /pmc/articles/PMC2874944/ /pubmed/20508848 http://dx.doi.org/10.1155/2010/263810 Text en Copyright © 2010 Kazumasa Hiroishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hiroishi, Kazumasa Eguchi, Junichi Ishii, Shigeaki Hiraide, Ayako Sakaki, Masashi Doi, Hiroyoshi Omori, Risa Imawari, Michio Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection |
title | Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection |
title_full | Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection |
title_fullStr | Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection |
title_full_unstemmed | Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection |
title_short | Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection |
title_sort | immune response of cytotoxic t lymphocytes and possibility of vaccine development for hepatitis c virus infection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874944/ https://www.ncbi.nlm.nih.gov/pubmed/20508848 http://dx.doi.org/10.1155/2010/263810 |
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