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UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

The anaphase-promoting complex (APC/C) ubiquitin ligase is the target of the spindle-assembly checkpoint (SAC), ubiquitylating protein substrates whose degradation regulates progress through mitosis1-3. The identity of the ubiquitin-conjugating (E2) enzymes that work with the APC/C is unclear. In an...

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Detalles Bibliográficos
Autores principales:	Garnett, Mathew J., Mansfeld, Jörg, Godwin, Colin, Matsusaka, Takahiro, Wu, Jiahua, Russell, Paul, Pines, Jonathon, Venkitaraman, Ashok R.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875106/ https://www.ncbi.nlm.nih.gov/pubmed/19820702 http://dx.doi.org/10.1038/ncb1983

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