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3′ uridylation precedes decapping in a novel pathway of bulk mRNA turnover
Both end structures of eukaryotic mRNAs, namely the 5′ cap and 3′ poly(A) tail, are necessary for transcript stability, and loss of either is sufficient to stimulate decay. mRNA turnover is classically thought to be initiated by deadenylation, as has been particularly well described in Saccharomyces...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875167/ https://www.ncbi.nlm.nih.gov/pubmed/19430462 http://dx.doi.org/10.1038/nsmb.1601 |