Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer

Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of these mutations are located within exons 18-21. The -216 single nucleotide polymorphism in the promoter region is...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Ching-Hsiung, Yeh, Kun-Tu, Chang, Ya-Sian, Hsu, Nicholas C, Chang, Jan-Gowth
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875208/
https://www.ncbi.nlm.nih.gov/pubmed/20459863
http://dx.doi.org/10.1186/1423-0127-17-37

Ejemplares similares

Ejemplares similares