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Epistatic and Functional Interactions of Catechol-O-Methyltransferase (COMT) and AKT1 on Neuregulin1-ErbB Signaling in Cell Models

BACKGROUND: Neuregulin1 (NRG1)-ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have previously reported that NRG1-stimulated migration of B lymphoblasts is PI3K-AKT1dependent and impaired in patients with schizophrenia and significantly linked to the catechol-o...

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Detalles Bibliográficos
Autores principales:	Sei, Yoshitatsu, Li, Zhen, Song, Jian, Ren-Patterson, Renee, Tunbridge, Elizabeth M., Iizuka, Yukihiko, Inoue, Masahiro, Alfonso, Berenice T., Beltaifa, Senda, Nakai, Yoko, Kolachana, Bhaskar S., Chen, Jingshan, Weinberger, Daniel R.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875391/ https://www.ncbi.nlm.nih.gov/pubmed/20520724 http://dx.doi.org/10.1371/journal.pone.0010789

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