Cargando…

Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes

OBJECTIVE: To assess the effects of exenatide on body weight and glucose tolerance in nondiabetic obese subjects with normal or impaired glucose tolerance (IGT) or impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS: Obese subjects (n = 152; age 46 ± 12 years, female 82%, weight 108.6 ± 23.0...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosenstock, Julio, Klaff, Leslie J., Schwartz, Sherwyn, Northrup, Justin, Holcombe, John H., Wilhelm, Kenneth, Trautmann, Michael
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875418/
https://www.ncbi.nlm.nih.gov/pubmed/20332357
http://dx.doi.org/10.2337/dc09-1203
_version_ 1782181568037519360
author Rosenstock, Julio
Klaff, Leslie J.
Schwartz, Sherwyn
Northrup, Justin
Holcombe, John H.
Wilhelm, Kenneth
Trautmann, Michael
author_facet Rosenstock, Julio
Klaff, Leslie J.
Schwartz, Sherwyn
Northrup, Justin
Holcombe, John H.
Wilhelm, Kenneth
Trautmann, Michael
author_sort Rosenstock, Julio
collection PubMed
description OBJECTIVE: To assess the effects of exenatide on body weight and glucose tolerance in nondiabetic obese subjects with normal or impaired glucose tolerance (IGT) or impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS: Obese subjects (n = 152; age 46 ± 12 years, female 82%, weight 108.6 ± 23.0 kg, BMI 39.6 ± 7.0 kg/m(2), IGT or IFG 25%) were randomized to receive exenatide (n = 73) or placebo (n = 79), along with lifestyle intervention, for 24 weeks. RESULTS: Exenatide-treated subjects lost 5.1 ± 0.5 kg from baseline versus 1.6 ± 0.5 kg with placebo (exenatide − placebo, P < 0.001). Placebo-subtracted difference in percent weight reduction was −3.3 ± 0.5% (P < 0.001). Both groups reduced their daily calorie intake (exenatide, −449 cal; placebo, −387 cal). IGT or IFG normalized at end point in 77 and 56% of exenatide and placebo subjects, respectively. CONCLUSIONS: Exenatide plus lifestyle modification decreased caloric intake and resulted in weight loss in nondiabetic obesity with improved glucose tolerance in subjects with IGT and IFG.
format Text
id pubmed-2875418
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-28754182011-06-01 Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes Rosenstock, Julio Klaff, Leslie J. Schwartz, Sherwyn Northrup, Justin Holcombe, John H. Wilhelm, Kenneth Trautmann, Michael Diabetes Care Original Research OBJECTIVE: To assess the effects of exenatide on body weight and glucose tolerance in nondiabetic obese subjects with normal or impaired glucose tolerance (IGT) or impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS: Obese subjects (n = 152; age 46 ± 12 years, female 82%, weight 108.6 ± 23.0 kg, BMI 39.6 ± 7.0 kg/m(2), IGT or IFG 25%) were randomized to receive exenatide (n = 73) or placebo (n = 79), along with lifestyle intervention, for 24 weeks. RESULTS: Exenatide-treated subjects lost 5.1 ± 0.5 kg from baseline versus 1.6 ± 0.5 kg with placebo (exenatide − placebo, P < 0.001). Placebo-subtracted difference in percent weight reduction was −3.3 ± 0.5% (P < 0.001). Both groups reduced their daily calorie intake (exenatide, −449 cal; placebo, −387 cal). IGT or IFG normalized at end point in 77 and 56% of exenatide and placebo subjects, respectively. CONCLUSIONS: Exenatide plus lifestyle modification decreased caloric intake and resulted in weight loss in nondiabetic obesity with improved glucose tolerance in subjects with IGT and IFG. American Diabetes Association 2010-06 2010-03-23 /pmc/articles/PMC2875418/ /pubmed/20332357 http://dx.doi.org/10.2337/dc09-1203 Text en © 2010 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Original Research
Rosenstock, Julio
Klaff, Leslie J.
Schwartz, Sherwyn
Northrup, Justin
Holcombe, John H.
Wilhelm, Kenneth
Trautmann, Michael
Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes
title Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes
title_full Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes
title_fullStr Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes
title_full_unstemmed Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes
title_short Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes
title_sort effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875418/
https://www.ncbi.nlm.nih.gov/pubmed/20332357
http://dx.doi.org/10.2337/dc09-1203
work_keys_str_mv AT rosenstockjulio effectsofexenatideandlifestylemodificationonbodyweightandglucosetoleranceinobesesubjectswithandwithoutprediabetes
AT klafflesliej effectsofexenatideandlifestylemodificationonbodyweightandglucosetoleranceinobesesubjectswithandwithoutprediabetes
AT schwartzsherwyn effectsofexenatideandlifestylemodificationonbodyweightandglucosetoleranceinobesesubjectswithandwithoutprediabetes
AT northrupjustin effectsofexenatideandlifestylemodificationonbodyweightandglucosetoleranceinobesesubjectswithandwithoutprediabetes
AT holcombejohnh effectsofexenatideandlifestylemodificationonbodyweightandglucosetoleranceinobesesubjectswithandwithoutprediabetes
AT wilhelmkenneth effectsofexenatideandlifestylemodificationonbodyweightandglucosetoleranceinobesesubjectswithandwithoutprediabetes
AT trautmannmichael effectsofexenatideandlifestylemodificationonbodyweightandglucosetoleranceinobesesubjectswithandwithoutprediabetes